The adult göttingen minipig as a model for chronic heart failure after myocardial infarction

focus on cardiovascular imaging and regenerative therapies

Karl H. Schuleri, Andrew J. Boyle, Marco Centola, Luciano C. Amado, Robert Evers, Jeffrey M. Zimmet, Kristine S. Evers, Katherine M. Ostbye, Diana G. Scorpio, Joshua M. Hare, Albert C. Lardo

Research output: Contribution to journalArticle

Abstract

Porcine models have become increasingly popular in cardiovascular research. The standard farm pig rapidly increases in body weight and size, potentially confounding serial measurements of cardiac function and morphology. We developed an adult porcine model that does not show physiologic increases in heart mass during the study period and is suitable for long-term study. We compared adult minipigs with the commonly used adolescent Yorkshire swine. Myocardial infarction was induced in adult Cöttingen minipigs and adolescent Yorkshire swine by occlusion of the left anterior descending coronary artery followed by reperfusion. At 8 wk after infarction, the left ventricular ejection fraction was 34.1 ± 2.3% in minipigs and 30.7 ± 2.0% in Yorkshire swine. The left ventricular end-diastolic mass in Yorkshire pigs assessed by magnetic resonance imaging increased 17 ± 5 g, from 42.6 ± 4.3 g at week 1 after infarction to 52.8 ± 6.6 g at week 8, whereas it remained unchanged in minipigs. Cardiac anatomy and physiology in adult minipigs were evaluated invasively by angiography and noninvasively by Multidetector Computed Tomography and by Magnetic Resonance Imaging at 1.5 T and 3 T prior to myocardial infarction and during folow-up. This porcine heart failure model is reproducible, mimics the pathophysiology in patients who have experienced myocardial infarction, and is suitable for imaging studies. New heart failure therapies and devices can be tested preclinically in this adult animal model of chronic heart failure.

Original languageEnglish (US)
Pages (from-to)568-579
Number of pages12
JournalComparative Medicine
Volume58
Issue number6
StatePublished - Dec 2008

Fingerprint

Miniature Swine
myocardial infarction
heart failure
Swine
Heart Failure
Myocardial Infarction
image analysis
Imaging techniques
therapeutics
swine
Yorkshire (swine breed)
Multidetector computed tomography
Angiography
infarction
Physiology
Magnetic resonance
Therapeutics
magnetic resonance imaging
Farms
Infarction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • veterinary(all)

Cite this

Schuleri, K. H., Boyle, A. J., Centola, M., Amado, L. C., Evers, R., Zimmet, J. M., ... Lardo, A. C. (2008). The adult göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies. Comparative Medicine, 58(6), 568-579.

The adult göttingen minipig as a model for chronic heart failure after myocardial infarction : focus on cardiovascular imaging and regenerative therapies. / Schuleri, Karl H.; Boyle, Andrew J.; Centola, Marco; Amado, Luciano C.; Evers, Robert; Zimmet, Jeffrey M.; Evers, Kristine S.; Ostbye, Katherine M.; Scorpio, Diana G.; Hare, Joshua M.; Lardo, Albert C.

In: Comparative Medicine, Vol. 58, No. 6, 12.2008, p. 568-579.

Research output: Contribution to journalArticle

Schuleri, KH, Boyle, AJ, Centola, M, Amado, LC, Evers, R, Zimmet, JM, Evers, KS, Ostbye, KM, Scorpio, DG, Hare, JM & Lardo, AC 2008, 'The adult göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies', Comparative Medicine, vol. 58, no. 6, pp. 568-579.
Schuleri, Karl H. ; Boyle, Andrew J. ; Centola, Marco ; Amado, Luciano C. ; Evers, Robert ; Zimmet, Jeffrey M. ; Evers, Kristine S. ; Ostbye, Katherine M. ; Scorpio, Diana G. ; Hare, Joshua M. ; Lardo, Albert C. / The adult göttingen minipig as a model for chronic heart failure after myocardial infarction : focus on cardiovascular imaging and regenerative therapies. In: Comparative Medicine. 2008 ; Vol. 58, No. 6. pp. 568-579.
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