The administration of dextrose during in-hospital cardiac arrest is associated with increased mortality and neurologic morbidity

and for the American Heart Association's Get With The Guidelines®-Resuscitation Investigators

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Abstract

Introduction: Dextrose may be used during cardiac arrest resuscitation to prevent or reverse hypoglycemia. However, the incidence of dextrose administration during cardiac arrest and the association of dextrose administration with survival and other outcomes are unknown. Methods: We used the Get With The Guidelines®-Resuscitation national registry to identify adult patients with an in-hospital cardiac arrest between the years 2000 and 2010. To assess the adjusted effects of dextrose administration on survival, we used multivariable regression models with adjustment for multiple patient, event, and hospital characteristics. We performed additional analyses to examine the effects of dextrose on neurological outcome and return of spontaneous circulation. Results: Among the 100,029 patients included in our study, 4,189 (4.2%) received dextrose during cardiac arrest resuscitation. The rate of dextrose administration increased during the study period (odds ratio 1.11, 95% confidence interval (CI) 1.09-1.12 per year, P

Original languageEnglish (US)
Article number160
JournalCritical Care
Volume19
Issue number1
DOIs
StatePublished - Apr 10 2015

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ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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