Abstract
Single injections of rat thyroid extract with complete Freund adjuvant were not consistent in eliciting significant thyroid pathology in Lewis rats. Identical treatment accompanied by a simultaneous but separate injection of 100 billion killed pertussis organisms was consistently effective in inducing marked thyroid changes at an earlier time. Lewis rats developed thyroid lesions approximately 1 week earlier than Fischer 344 rats receiving the same treatment. Pertussis vaccine also seemed to increase the level of circulating autoantibodies to thyroid.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 434-439 |
| Number of pages | 6 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 130 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1969 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology