Single injections of rat thyroid extract with complete Freund adjuvant were not consistent in eliciting significant thyroid pathology in Lewis rats. Identical treatment accompanied by a simultaneous but separate injection of 100 billion killed pertussis organisms was consistently effective in inducing marked thyroid changes at an earlier time. Lewis rats developed thyroid lesions approximately 1 week earlier than Fischer 344 rats receiving the same treatment. Pertussis vaccine also seemed to increase the level of circulating autoantibodies to thyroid.
|Original language||English (US)|
|Number of pages||6|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Feb 1969|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)