The Adjuvant Effect of Pertussis Vaccine in Experimental Thyroiditis of the Rat

Frank J. Twarog, Noel R. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Single injections of rat thyroid extract with complete Freund adjuvant were not consistent in eliciting significant thyroid pathology in Lewis rats. Identical treatment accompanied by a simultaneous but separate injection of 100 billion killed pertussis organisms was consistently effective in inducing marked thyroid changes at an earlier time. Lewis rats developed thyroid lesions approximately 1 week earlier than Fischer 344 rats receiving the same treatment. Pertussis vaccine also seemed to increase the level of circulating autoantibodies to thyroid.

Original languageEnglish (US)
Pages (from-to)434-439
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume130
Issue number2
DOIs
StatePublished - Feb 1969

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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