The adaptable somatic repertoire

P. J. Gearhart

Research output: Contribution to journalArticle

Abstract

Somatic mutation introduces singles nucleotide substitutions in and around the rearranged kappa variable gene, Vk167, but not the constant gene. The high frequency of mutations is most easily explained by a mechanism of error-prone repair which occurs during several cycles of cell division. Mutations may accumulate with time after joining of the V- and J-gene segments because IgG and IgA antibodies contain more amino acid substitutions than IgM antibodies. Many variant anti-phosphorylcholine antibodies have a higher affinity for antigen than their germ-line-encoded counterparts.

Original languageEnglish (US)
Pages (from-to)137-142
Number of pages6
JournalAnnales de l'Institut Pasteur - Immunology
Volume135
Issue number1
DOIs
StatePublished - Jan 1 1984

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Keywords

  • Antibody repertoire
  • Immunogenetics.
  • Immunogénétique
  • Phosphorylcholine
  • Phosphorylcholine
  • Répertoire anticorps

ASJC Scopus subject areas

  • Medicine(all)

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