The acute phase response and atherosclerosis

Charles Lowenstein, Kenji Matsushita

Research output: Contribution to journalArticlepeer-review


The acute phase response (APR) is an acute systemic response to infection. Recent studies reveal that the APR is chronically activated in patients at risk for atherosclerosis. Diabetes, hypertension, and elevated cholesterol trigger the APR, leading to the systemic release of hundreds of effector molecules that might damage the endothelium and activate macrophages, driving the process of atherogenesis. The signaling molecules that mediate the APR are attractive candidates for anti-inflammatory therapy of patients with atherosclerosis.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalDrug Discovery Today: Disease Mechanisms
Issue number1
StatePublished - Oct 2004

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine


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