TY - JOUR
T1 - The acute phase response and atherosclerosis
AU - Lowenstein, Charles
AU - Matsushita, Kenji
PY - 2004/10
Y1 - 2004/10
N2 - The acute phase response (APR) is an acute systemic response to infection. Recent studies reveal that the APR is chronically activated in patients at risk for atherosclerosis. Diabetes, hypertension, and elevated cholesterol trigger the APR, leading to the systemic release of hundreds of effector molecules that might damage the endothelium and activate macrophages, driving the process of atherogenesis. The signaling molecules that mediate the APR are attractive candidates for anti-inflammatory therapy of patients with atherosclerosis.
AB - The acute phase response (APR) is an acute systemic response to infection. Recent studies reveal that the APR is chronically activated in patients at risk for atherosclerosis. Diabetes, hypertension, and elevated cholesterol trigger the APR, leading to the systemic release of hundreds of effector molecules that might damage the endothelium and activate macrophages, driving the process of atherogenesis. The signaling molecules that mediate the APR are attractive candidates for anti-inflammatory therapy of patients with atherosclerosis.
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U2 - 10.1016/j.ddmec.2004.08.001
DO - 10.1016/j.ddmec.2004.08.001
M3 - Review article
AN - SCOPUS:23744497661
SN - 1740-6765
VL - 1
SP - 17
EP - 22
JO - Drug Discovery Today: Disease Mechanisms
JF - Drug Discovery Today: Disease Mechanisms
IS - 1
ER -