The Actomyosin Cytoskeleton Drives Micron-Scale Membrane Remodeling In Vivo Via the Generation of Mechanical Forces to Balance Membrane Tension Gradients

Seham Ebrahim, Jian Liu, Roberto Weigert

Research output: Contribution to journalReview articlepeer-review

Abstract

The remodeling of biological membranes is crucial for a vast number of cellular activities and is an inherently multiscale process in both time and space. Seminal work has provided important insights into nanometer-scale membrane deformations, and highlighted the remarkable variation and complexity in the underlying molecular machineries and mechanisms. However, how membranes are remodeled at the micron-scale, particularly in vivo, remains poorly understood. Here, we discuss how using regulated exocytosis of large (1.5–2.0 μm) membrane-bound secretory granules in the salivary gland of live mice as a model system, has provided evidence for the importance of the actomyosin cytoskeleton in micron-scale membrane remodeling in physiological conditions. We highlight some of these advances, and present mechanistic hypotheses for how the various biochemical and biophysical properties of distinct actomyosin networks may drive this process.

Original languageEnglish (US)
Article number1800032
JournalBioEssays
Volume40
Issue number9
DOIs
StatePublished - Sep 2018
Externally publishedYes

Keywords

  • actomyosin
  • cytoskeleton
  • in vivo
  • intravital microscopy
  • membrane remodeling
  • micron-scale
  • regulated exocytosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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