ACTIVITE DE LA RIFAMPICINE ADMINISTREE DE MANIERE INTERMITTENTE ET DE LA CYCLOPENTYL RIFAMYCINE (OU DL473) SUR LA TUBERCULOSE EXPERIMENTALE DE LA SOURIS

Translated title of the contribution: The activity of intermittent Rifampicin and Cyclopentyl Rifampicin (or DL473) on experimental tuberculosis in the mouse

Ch Truffot-Pernot, J. Grosset, R. Bismuth, H. Lecoeur

Research output: Contribution to journalArticle

Abstract

The results of recent experiences with experimental tuberculous chemotherapy in the mouse give information on the activity of rifampicin (RMP) administered intermittently and on the activity of Cyclopentyl-Rifampicin (or DL473). The activity of RMP decreases as one spaces the treatment without increasing the dose. These observations are compatible with the known facts concerning the mechanism of action of RMP on RNA polymerase, and are unfavourable as regards the intermittent administration of RMP. Cyclopentyl-Rifampicin, a new derivative of Rifamycine SV, administered once per week, is as active as RMP administered six days per week, both in the initial as well as the continuation phase of treatment.

Translated title of the contributionThe activity of intermittent Rifampicin and Cyclopentyl Rifampicin (or DL473) on experimental tuberculosis in the mouse
Original languageFrench
Pages (from-to)875-882
Number of pages8
JournalRevue Francaise des Maladies Respiratoires
Volume11
Issue number6
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'The activity of intermittent Rifampicin and Cyclopentyl Rifampicin (or DL473) on experimental tuberculosis in the mouse'. Together they form a unique fingerprint.

  • Cite this