TY - JOUR
T1 - The active E rosette test
T2 - correlation with delayed cutaneous hypersensitivity
AU - Felsburg, P. J.
AU - Edelman, R.
AU - Gilman, R. H.
PY - 1976/12/1
Y1 - 1976/12/1
N2 - An active subpopulation of peripheral blood T lymphocytes, characterized by rapid (5 min) rosette formation with sheep erythrocytes (A RFC) was measured in normal individuals after they were skin tested with microbial antigens. A significant rise in A RFC occurred in all individuals who developed positive delayed cutaneous hypersensitivity (DCH) reactions, whereas skin test nonresponders showed no significant rise in A RFC. No similar consistent changes occured in populations of total T cells, characterized by longer (60 min) rosette formation with sheep erythrocytes, or in B cells, measured by immunofluorescence of surface immunoglobulin. The A RFC response paralleled the DCH response in timing, but not in intensity. The results provide in vivo evidence for a biologically distinct T cell subpopulation, and focus attention on the A RFC as immunologically active cells.
AB - An active subpopulation of peripheral blood T lymphocytes, characterized by rapid (5 min) rosette formation with sheep erythrocytes (A RFC) was measured in normal individuals after they were skin tested with microbial antigens. A significant rise in A RFC occurred in all individuals who developed positive delayed cutaneous hypersensitivity (DCH) reactions, whereas skin test nonresponders showed no significant rise in A RFC. No similar consistent changes occured in populations of total T cells, characterized by longer (60 min) rosette formation with sheep erythrocytes, or in B cells, measured by immunofluorescence of surface immunoglobulin. The A RFC response paralleled the DCH response in timing, but not in intensity. The results provide in vivo evidence for a biologically distinct T cell subpopulation, and focus attention on the A RFC as immunologically active cells.
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M3 - Article
C2 - 1082906
AN - SCOPUS:0017224918
SN - 0022-1767
VL - 116
SP - 1110
EP - 1114
JO - Journal of Immunology
JF - Journal of Immunology
IS - 4
ER -