The activation of Lymphocytes is in their CARMA

Abul K. Abbas, Ranjan Sen

Research output: Contribution to journalArticlepeer-review


Lymphocyte activation via antigen receptors initiates adaptive immune responses. Two papers in this issue of Immunity demonstrate that CARMA-1, a CARD carrying member of the MAGUK family proteins, is essential for lymphocyte activation. CARMA-1 functions by coupling antigen receptor signals to NF-κB induction and JNK activation.

Original languageEnglish (US)
Pages (from-to)721-722
Number of pages2
Issue number6
StatePublished - Jun 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology

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