The action of Lipoxin-A on glomerular microcirculatory dynamics in the rat

Kamal F. Badr, Charles N. Serhan, K. C. Nicolaou, Bengt Samuelsson

Research output: Contribution to journalArticlepeer-review

Abstract

Intrarenal administration of 750 ng/kg/min of LX-A in euvolemic rats resulted in significant increases in single nephron GFR (38.4±1.7 to 45.5±3.0 nl/min) and plasma flow rate (95±6 to 127±9 nl/min). The latter was due to a dramatic fall in afferent arteriolar resistance. Mean transcapillary hydraulic pressure difference increased from 33±1 to 43±3 mmHg (p

Original languageEnglish (US)
Pages (from-to)408-414
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume145
Issue number1
DOIs
StatePublished - May 29 1987
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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