The accuracy of target delineation in laryngeal and hypopharyngeal cancer

Joana Caldas-Magalhaes, Nina Kooij, Hans Ligtenberg, Elise A. Jager, Tim Schakel, Nicolien Kasperts, Frank A. Pameijer, Chris H J Terhaard, Luuk M. Janssen, Paul J. Van Diest, Marielle E P Philippens, Cornelis P J Raaijmakers

Research output: Contribution to journalArticle

Abstract

Background and purpose. To determine the spatial correspondence between the gross tumor volume (GTV) delineated on computer tomography (CT) and the actual tumor on histopathology.Material and methods. Sixteen patients with T3 or T4 laryngeal or hypopharyngeal cancer underwent a CT scan before total laryngectomy. The GTV was delineated on CT by three independent observers and by consensus between the three observers. After surgery, whole-mount hematoxylin-eosin stained (H&E) sections were obtained. One pathologist delineated the tumor in the H&E sections (tumorH&E). The reconstructed specimen was registered to the CT scan in order to compare the GTV to the tumorH&E in three dimensions. The overlap between the GTV and the tumorH&E was calculated and the distance between the volumes was determined.Results. Tumor tissue was delineated in 203 of 516 H&E sections. For 14 patients a detailed analysis could be performed. The GTV volume was on average 1.7 times larger than the volume of the tumorH&E. The mean coverage of the tumorH&E by the consensus GTV was 88%. tumorH&E tissue was found at 1.6 mm to 12.9 mm distance outside the GTV depending on observer and patient.Conclusions. GTVs delineated on CT for laryngeal and hypopharyngeal cancer were 1.7 times larger than the tumor. Complete coverage of the tumor by the GTV was, however, not obtained.

Original languageEnglish (US)
Pages (from-to)1181-1187
Number of pages7
JournalActa Oncologica
Volume54
Issue number8
DOIs
StatePublished - Sep 14 2015
Externally publishedYes

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Hypopharyngeal Neoplasms
Laryngeal Neoplasms
Tumor Burden
Tomography
Neoplasms
Laryngectomy
Hematoxylin
Eosine Yellowish-(YS)

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Hematology

Cite this

Caldas-Magalhaes, J., Kooij, N., Ligtenberg, H., Jager, E. A., Schakel, T., Kasperts, N., ... Raaijmakers, C. P. J. (2015). The accuracy of target delineation in laryngeal and hypopharyngeal cancer. Acta Oncologica, 54(8), 1181-1187. https://doi.org/10.3109/0284186X.2015.1006401

The accuracy of target delineation in laryngeal and hypopharyngeal cancer. / Caldas-Magalhaes, Joana; Kooij, Nina; Ligtenberg, Hans; Jager, Elise A.; Schakel, Tim; Kasperts, Nicolien; Pameijer, Frank A.; Terhaard, Chris H J; Janssen, Luuk M.; Van Diest, Paul J.; Philippens, Marielle E P; Raaijmakers, Cornelis P J.

In: Acta Oncologica, Vol. 54, No. 8, 14.09.2015, p. 1181-1187.

Research output: Contribution to journalArticle

Caldas-Magalhaes, J, Kooij, N, Ligtenberg, H, Jager, EA, Schakel, T, Kasperts, N, Pameijer, FA, Terhaard, CHJ, Janssen, LM, Van Diest, PJ, Philippens, MEP & Raaijmakers, CPJ 2015, 'The accuracy of target delineation in laryngeal and hypopharyngeal cancer', Acta Oncologica, vol. 54, no. 8, pp. 1181-1187. https://doi.org/10.3109/0284186X.2015.1006401
Caldas-Magalhaes J, Kooij N, Ligtenberg H, Jager EA, Schakel T, Kasperts N et al. The accuracy of target delineation in laryngeal and hypopharyngeal cancer. Acta Oncologica. 2015 Sep 14;54(8):1181-1187. https://doi.org/10.3109/0284186X.2015.1006401
Caldas-Magalhaes, Joana ; Kooij, Nina ; Ligtenberg, Hans ; Jager, Elise A. ; Schakel, Tim ; Kasperts, Nicolien ; Pameijer, Frank A. ; Terhaard, Chris H J ; Janssen, Luuk M. ; Van Diest, Paul J. ; Philippens, Marielle E P ; Raaijmakers, Cornelis P J. / The accuracy of target delineation in laryngeal and hypopharyngeal cancer. In: Acta Oncologica. 2015 ; Vol. 54, No. 8. pp. 1181-1187.
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