TY - JOUR
T1 - The absence of task-related increases in BOLD signal does not equate to absence of task-related brain activation
AU - Xu, Jiansong
AU - Calhoun, Vince D.
AU - Potenza, Marc N.
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Most fMRI studies employ general-linear-model-based analyses (GLM-BA) of BOLD signal changes to identify regions that are active (or not) during specific cognitive processes. However, alternate analytic approaches (like independent component analysis) may identify more complex patterns of activation, including in regions not implicated in GLM-BA of the same data. In our opinion, fMRI findings revealed by a GLM-BA cannot exclude any brain regions from contributing to specific cognitive processes.
AB - Most fMRI studies employ general-linear-model-based analyses (GLM-BA) of BOLD signal changes to identify regions that are active (or not) during specific cognitive processes. However, alternate analytic approaches (like independent component analysis) may identify more complex patterns of activation, including in regions not implicated in GLM-BA of the same data. In our opinion, fMRI findings revealed by a GLM-BA cannot exclude any brain regions from contributing to specific cognitive processes.
KW - Balanced excitation and inhibition
KW - Functional heterogeneity
KW - General linear model
KW - Spatial independent component analysis
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U2 - 10.1016/j.jneumeth.2014.11.002
DO - 10.1016/j.jneumeth.2014.11.002
M3 - Article
C2 - 25445055
AN - SCOPUS:84916195949
SN - 0165-0270
VL - 240
SP - 125
EP - 127
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
ER -