The Abnormal Regulation of Gene Expression in Autistic Brain Tissue

Amy E. Purcell, Ok Hee Jeon, Jonathan Pevsner

Research output: Contribution to journalReview article

Abstract

Autism is a pervasive developmental disorder of unknown etiology. It is likely caused by mutations in one or more genes. One approach to understanding the molecular changes that occur in autism is to measure gene expression in post-mortem brain samples from individuals diagnosed with autism. This may be accomplished with techniques such as cDNA microarrays or subtractive hybridization. In general, gene expression is regulated as a function of body region, developmental time, and physiological state. A premise of the approaches we describe is that gene expression is regulated in cells from autistic individuals as a consequence of the disease process. It may be useful to detect such changes in order to identify selective biological markers for autism. Additionally, the abnormal regulation of gene expression may reveal cellular pathways that have been disrupted, suggesting strategies for therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)545-549
Number of pages5
JournalJournal of Autism and Developmental Disorders
Volume31
Issue number6
DOIs
StatePublished - Dec 1 2001

Keywords

  • Diagnostic test
  • Pervasive developmental disorder
  • Subtractive hybridization
  • cDNA microarray

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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