TY - JOUR
T1 - The 2D:4D ratio, a proxy for prenatal androgen levels, differs in men with and without MS
AU - Bove, Riley
AU - Malik, Muhammed T.
AU - Diaz-Cruz, Camilo
AU - Chua, Alicia
AU - Saraceno, Taylor J.
AU - Bargiela, David
AU - Greeke, Emily
AU - Glanz, Bonnie I.
AU - Healy, Brian C.
AU - Chitnis, Tanuja
N1 - Publisher Copyright:
© 2015 American Academy of Neurology.
PY - 2015/10/6
Y1 - 2015/10/6
N2 - Objective: To determine whether the 2D:4D ratio (ratio of the second and fourth digit lengths), a proxy for lower prenatal androgen to estrogen ratio, differs in men with and without multiple sclerosis (MS) using a case-control study design. Methods: We obtained 2 digital scans of the right hand for men with MS presenting to a scheduled clinic visit at a large MS referral center, and for men without autoimmune or endocrine diseases. All individuals were aged 18 to 65 years, right-handed, and reported no prior digit trauma. We calculated a mean 2D:4D ratio using digital calipers. In participants with MS, we assessed age at first MS symptoms, MS type, and the MS Severity Score; 51 had provided a testosterone level within 10 years of symptom onset. Our primary analysis was a cross-sectional comparison of the 2D:4D ratio between men with and without MS, using a 2-sample t test for independent samples assuming unequal variance. Results: In total, we scanned 137 men with MS and 145 men without MS. A statistically significant association between 2D:4D ratio and MS status was observed in the univariate logistic regression model (p < 0.05). These differences were not associated with age or race, which differed between the 2 groups. In participants with MS, the 2D:4D ratio was not correlated with MS type, age at first symptoms, or MS Severity Score (p > 0.15 for each), and it was not correlated with adult testosterone levels (r 0.06, p 0.68, n 51). Conclusions: During the prenatal period, low androgens could represent a risk factor for MS.
AB - Objective: To determine whether the 2D:4D ratio (ratio of the second and fourth digit lengths), a proxy for lower prenatal androgen to estrogen ratio, differs in men with and without multiple sclerosis (MS) using a case-control study design. Methods: We obtained 2 digital scans of the right hand for men with MS presenting to a scheduled clinic visit at a large MS referral center, and for men without autoimmune or endocrine diseases. All individuals were aged 18 to 65 years, right-handed, and reported no prior digit trauma. We calculated a mean 2D:4D ratio using digital calipers. In participants with MS, we assessed age at first MS symptoms, MS type, and the MS Severity Score; 51 had provided a testosterone level within 10 years of symptom onset. Our primary analysis was a cross-sectional comparison of the 2D:4D ratio between men with and without MS, using a 2-sample t test for independent samples assuming unequal variance. Results: In total, we scanned 137 men with MS and 145 men without MS. A statistically significant association between 2D:4D ratio and MS status was observed in the univariate logistic regression model (p < 0.05). These differences were not associated with age or race, which differed between the 2 groups. In participants with MS, the 2D:4D ratio was not correlated with MS type, age at first symptoms, or MS Severity Score (p > 0.15 for each), and it was not correlated with adult testosterone levels (r 0.06, p 0.68, n 51). Conclusions: During the prenatal period, low androgens could represent a risk factor for MS.
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U2 - 10.1212/WNL.0000000000001990
DO - 10.1212/WNL.0000000000001990
M3 - Article
C2 - 26341868
AN - SCOPUS:84943240884
SN - 0028-3878
VL - 85
SP - 1209
EP - 1213
JO - Neurology
JF - Neurology
IS - 14
ER -