The 2014 San Antonio breast cancer symposium: A successful lift-off for breast immunotherapy?

David B. Page, Jarushka Naidoo, Heather L. McArthur

Research output: Contribution to journalArticle

Abstract

Therapeutic immune checkpoint antibodies promote potentially durable cancer control by modulating key regulatory factors of the endogenous anti-tumor immune response. The first clinical trial data of these agents in breast cancer were presented at the 2014 San Antonio Breast Cancer Symposium, with seemingly modest response rates compared with metastatic melanoma and Hodgkin’s lymphoma. In this article, we review the San Antonio immunotherapy data, drawing key analogies to historical experiences in metastatic melanoma that support an enthusiastic outlook for immunotherapy in breast cancer.

Original languageEnglish (US)
Article number15001
Journalnpj Breast Cancer
Volume1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Immunotherapy
Melanoma
Breast
Breast Neoplasms
Hodgkin Disease
Neoplasms
Clinical Trials
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Pharmacology (medical)

Cite this

The 2014 San Antonio breast cancer symposium : A successful lift-off for breast immunotherapy? / Page, David B.; Naidoo, Jarushka; McArthur, Heather L.

In: npj Breast Cancer, Vol. 1, 15001, 01.01.2015.

Research output: Contribution to journalArticle

@article{a3c545bb294f47fdbf4572de09d7552b,
title = "The 2014 San Antonio breast cancer symposium: A successful lift-off for breast immunotherapy?",
abstract = "Therapeutic immune checkpoint antibodies promote potentially durable cancer control by modulating key regulatory factors of the endogenous anti-tumor immune response. The first clinical trial data of these agents in breast cancer were presented at the 2014 San Antonio Breast Cancer Symposium, with seemingly modest response rates compared with metastatic melanoma and Hodgkin’s lymphoma. In this article, we review the San Antonio immunotherapy data, drawing key analogies to historical experiences in metastatic melanoma that support an enthusiastic outlook for immunotherapy in breast cancer.",
author = "Page, {David B.} and Jarushka Naidoo and McArthur, {Heather L.}",
year = "2015",
month = "1",
day = "1",
doi = "10.1038/npjbcancer.2015.1",
language = "English (US)",
volume = "1",
journal = "npj Breast Cancer",
issn = "2374-4677",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - The 2014 San Antonio breast cancer symposium

T2 - A successful lift-off for breast immunotherapy?

AU - Page, David B.

AU - Naidoo, Jarushka

AU - McArthur, Heather L.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Therapeutic immune checkpoint antibodies promote potentially durable cancer control by modulating key regulatory factors of the endogenous anti-tumor immune response. The first clinical trial data of these agents in breast cancer were presented at the 2014 San Antonio Breast Cancer Symposium, with seemingly modest response rates compared with metastatic melanoma and Hodgkin’s lymphoma. In this article, we review the San Antonio immunotherapy data, drawing key analogies to historical experiences in metastatic melanoma that support an enthusiastic outlook for immunotherapy in breast cancer.

AB - Therapeutic immune checkpoint antibodies promote potentially durable cancer control by modulating key regulatory factors of the endogenous anti-tumor immune response. The first clinical trial data of these agents in breast cancer were presented at the 2014 San Antonio Breast Cancer Symposium, with seemingly modest response rates compared with metastatic melanoma and Hodgkin’s lymphoma. In this article, we review the San Antonio immunotherapy data, drawing key analogies to historical experiences in metastatic melanoma that support an enthusiastic outlook for immunotherapy in breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=85060379816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85060379816&partnerID=8YFLogxK

U2 - 10.1038/npjbcancer.2015.1

DO - 10.1038/npjbcancer.2015.1

M3 - Article

AN - SCOPUS:85060379816

VL - 1

JO - npj Breast Cancer

JF - npj Breast Cancer

SN - 2374-4677

M1 - 15001

ER -