The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design

Ruth E. Patterson, Graham A. Colditz, Frank B. Hu, Kathryn H. Schmitz, Rexford S Ahima, Ross C. Brownson, Kenneth R. Carson, Jorge E. Chavarro, Lewis A. Chodosh, Sarah Gehlert, Jeff Gill, Karen Glanz, Debra Haire-Joshu, Karen Louise Herbst, Christine M. Hoehner, Peter S. Hovmand, Melinda L. Irwin, Linda A. Jacobs, Aimee S. James, Lee W. JonesJacqueline Kerr, Adam S. Kibel, Irena B. King, Jennifer A. Ligibel, Jeffrey A. Meyerhardt, Loki Natarajan, Marian L. Neuhouser, Jerrold M. Olefsky, Enola K. Proctor, Susan Redline, Cheryl L. Rock, Bernard Rosner, David B. Sarwer, J. Sanford Schwartz, Dorothy D. Sears, Howard D. Sesso, Meir J. Stampfer, S. V. Subramanian, Elsie M. Taveras, Julia Tchou, Beti Thompson, Andrea B. Troxel, Marianne Wessling-Resnick, Kathleen Y. Wolin, Mark D. Thornquist

Research output: Contribution to journalArticle

Abstract

Purpose: Recognition of the complex, multidimensional relationship between excess adiposity and cancer control outcomes has motivated the scientific community to seek new research models and paradigms. Methods: The National Cancer Institute developed an innovative concept to establish a center grant mechanism in nutrition, energetics, and physical activity, referred to as the Transdisciplinary Research on Energetics and Cancer (TREC) Initiative. This paper gives an overview of the 2011-2016 TREC Collaborative Network and the 15 research projects being conducted at the centers. Results: Four academic institutions were awarded TREC center grants in 2011: Harvard University, University of California San Diego, University of Pennsylvania, and Washington University in St. Louis. The Fred Hutchinson Cancer Research Center is the Coordination Center. The TREC research portfolio includes three animal studies, three cohort studies, four randomized clinical trials, one cross-sectional study, and two modeling studies. Disciplines represented by TREC investigators include basic science, endocrinology, epidemiology, biostatistics, behavior, medicine, nutrition, physical activity, genetics, engineering, health economics, and computer science. Approximately 41,000 participants will be involved in these studies, including children, healthy adults, and breast and prostate cancer survivors. Outcomes include biomarkers of cancer risk, changes in weight and physical activity, persistent adverse treatment effects (e.g., lymphedema, urinary and sexual function), and breast and prostate cancer mortality. Conclusion: The NIH Science of Team Science group will evaluate the value added by this collaborative science. However, the most important outcome will be whether this transdisciplinary initiative improves the health of Americans at risk of cancer as well as cancer survivors.

Original languageEnglish (US)
Pages (from-to)695-704
Number of pages10
JournalCancer Causes and Control
Volume24
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Fingerprint

Research
Neoplasms
Organized Financing
Exercise
Survivors
Prostatic Neoplasms
Biostatistics
Breast Neoplasms
Genetic Engineering
Lymphedema
National Cancer Institute (U.S.)
Endocrinology
Adiposity
Health
Tumor Biomarkers
Epidemiology
Cohort Studies
Randomized Controlled Trials
Cross-Sectional Studies
Economics

Keywords

  • Cancer
  • Diet
  • Energetics
  • Obesity
  • Physical activity
  • Transdisciplinary

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Patterson, R. E., Colditz, G. A., Hu, F. B., Schmitz, K. H., Ahima, R. S., Brownson, R. C., ... Thornquist, M. D. (2013). The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design. Cancer Causes and Control, 24(4), 695-704. https://doi.org/10.1007/s10552-013-0150-z

The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative : Rationale and Design. / Patterson, Ruth E.; Colditz, Graham A.; Hu, Frank B.; Schmitz, Kathryn H.; Ahima, Rexford S; Brownson, Ross C.; Carson, Kenneth R.; Chavarro, Jorge E.; Chodosh, Lewis A.; Gehlert, Sarah; Gill, Jeff; Glanz, Karen; Haire-Joshu, Debra; Herbst, Karen Louise; Hoehner, Christine M.; Hovmand, Peter S.; Irwin, Melinda L.; Jacobs, Linda A.; James, Aimee S.; Jones, Lee W.; Kerr, Jacqueline; Kibel, Adam S.; King, Irena B.; Ligibel, Jennifer A.; Meyerhardt, Jeffrey A.; Natarajan, Loki; Neuhouser, Marian L.; Olefsky, Jerrold M.; Proctor, Enola K.; Redline, Susan; Rock, Cheryl L.; Rosner, Bernard; Sarwer, David B.; Schwartz, J. Sanford; Sears, Dorothy D.; Sesso, Howard D.; Stampfer, Meir J.; Subramanian, S. V.; Taveras, Elsie M.; Tchou, Julia; Thompson, Beti; Troxel, Andrea B.; Wessling-Resnick, Marianne; Wolin, Kathleen Y.; Thornquist, Mark D.

In: Cancer Causes and Control, Vol. 24, No. 4, 04.2013, p. 695-704.

Research output: Contribution to journalArticle

Patterson, RE, Colditz, GA, Hu, FB, Schmitz, KH, Ahima, RS, Brownson, RC, Carson, KR, Chavarro, JE, Chodosh, LA, Gehlert, S, Gill, J, Glanz, K, Haire-Joshu, D, Herbst, KL, Hoehner, CM, Hovmand, PS, Irwin, ML, Jacobs, LA, James, AS, Jones, LW, Kerr, J, Kibel, AS, King, IB, Ligibel, JA, Meyerhardt, JA, Natarajan, L, Neuhouser, ML, Olefsky, JM, Proctor, EK, Redline, S, Rock, CL, Rosner, B, Sarwer, DB, Schwartz, JS, Sears, DD, Sesso, HD, Stampfer, MJ, Subramanian, SV, Taveras, EM, Tchou, J, Thompson, B, Troxel, AB, Wessling-Resnick, M, Wolin, KY & Thornquist, MD 2013, 'The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative: Rationale and Design', Cancer Causes and Control, vol. 24, no. 4, pp. 695-704. https://doi.org/10.1007/s10552-013-0150-z
Patterson, Ruth E. ; Colditz, Graham A. ; Hu, Frank B. ; Schmitz, Kathryn H. ; Ahima, Rexford S ; Brownson, Ross C. ; Carson, Kenneth R. ; Chavarro, Jorge E. ; Chodosh, Lewis A. ; Gehlert, Sarah ; Gill, Jeff ; Glanz, Karen ; Haire-Joshu, Debra ; Herbst, Karen Louise ; Hoehner, Christine M. ; Hovmand, Peter S. ; Irwin, Melinda L. ; Jacobs, Linda A. ; James, Aimee S. ; Jones, Lee W. ; Kerr, Jacqueline ; Kibel, Adam S. ; King, Irena B. ; Ligibel, Jennifer A. ; Meyerhardt, Jeffrey A. ; Natarajan, Loki ; Neuhouser, Marian L. ; Olefsky, Jerrold M. ; Proctor, Enola K. ; Redline, Susan ; Rock, Cheryl L. ; Rosner, Bernard ; Sarwer, David B. ; Schwartz, J. Sanford ; Sears, Dorothy D. ; Sesso, Howard D. ; Stampfer, Meir J. ; Subramanian, S. V. ; Taveras, Elsie M. ; Tchou, Julia ; Thompson, Beti ; Troxel, Andrea B. ; Wessling-Resnick, Marianne ; Wolin, Kathleen Y. ; Thornquist, Mark D. / The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative : Rationale and Design. In: Cancer Causes and Control. 2013 ; Vol. 24, No. 4. pp. 695-704.
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T1 - The 2011-2016 Transdisciplinary Research on Energetics and Cancer (TREC) Initiative

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AU - Patterson, Ruth E.

AU - Colditz, Graham A.

AU - Hu, Frank B.

AU - Schmitz, Kathryn H.

AU - Ahima, Rexford S

AU - Brownson, Ross C.

AU - Carson, Kenneth R.

AU - Chavarro, Jorge E.

AU - Chodosh, Lewis A.

AU - Gehlert, Sarah

AU - Gill, Jeff

AU - Glanz, Karen

AU - Haire-Joshu, Debra

AU - Herbst, Karen Louise

AU - Hoehner, Christine M.

AU - Hovmand, Peter S.

AU - Irwin, Melinda L.

AU - Jacobs, Linda A.

AU - James, Aimee S.

AU - Jones, Lee W.

AU - Kerr, Jacqueline

AU - Kibel, Adam S.

AU - King, Irena B.

AU - Ligibel, Jennifer A.

AU - Meyerhardt, Jeffrey A.

AU - Natarajan, Loki

AU - Neuhouser, Marian L.

AU - Olefsky, Jerrold M.

AU - Proctor, Enola K.

AU - Redline, Susan

AU - Rock, Cheryl L.

AU - Rosner, Bernard

AU - Sarwer, David B.

AU - Schwartz, J. Sanford

AU - Sears, Dorothy D.

AU - Sesso, Howard D.

AU - Stampfer, Meir J.

AU - Subramanian, S. V.

AU - Taveras, Elsie M.

AU - Tchou, Julia

AU - Thompson, Beti

AU - Troxel, Andrea B.

AU - Wessling-Resnick, Marianne

AU - Wolin, Kathleen Y.

AU - Thornquist, Mark D.

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N2 - Purpose: Recognition of the complex, multidimensional relationship between excess adiposity and cancer control outcomes has motivated the scientific community to seek new research models and paradigms. Methods: The National Cancer Institute developed an innovative concept to establish a center grant mechanism in nutrition, energetics, and physical activity, referred to as the Transdisciplinary Research on Energetics and Cancer (TREC) Initiative. This paper gives an overview of the 2011-2016 TREC Collaborative Network and the 15 research projects being conducted at the centers. Results: Four academic institutions were awarded TREC center grants in 2011: Harvard University, University of California San Diego, University of Pennsylvania, and Washington University in St. Louis. The Fred Hutchinson Cancer Research Center is the Coordination Center. The TREC research portfolio includes three animal studies, three cohort studies, four randomized clinical trials, one cross-sectional study, and two modeling studies. Disciplines represented by TREC investigators include basic science, endocrinology, epidemiology, biostatistics, behavior, medicine, nutrition, physical activity, genetics, engineering, health economics, and computer science. Approximately 41,000 participants will be involved in these studies, including children, healthy adults, and breast and prostate cancer survivors. Outcomes include biomarkers of cancer risk, changes in weight and physical activity, persistent adverse treatment effects (e.g., lymphedema, urinary and sexual function), and breast and prostate cancer mortality. Conclusion: The NIH Science of Team Science group will evaluate the value added by this collaborative science. However, the most important outcome will be whether this transdisciplinary initiative improves the health of Americans at risk of cancer as well as cancer survivors.

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KW - Cancer

KW - Diet

KW - Energetics

KW - Obesity

KW - Physical activity

KW - Transdisciplinary

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