The 1,2,3-benzothiadiazoles. A new type of compound acting on coupling site i, in rat liver mitochondria

D. L. Gil, J. Ferreira, B. Reynafarje

Research output: Contribution to journalArticlepeer-review

Abstract

1. In rat liver mitochondria, 6-chloro-1,2,3-benzothiadiazole inhibited ADP phosphorylation and Ca2+-transport when the energy required for these processes came from the oxidation of NAD-linked substrates. The inhibition was characterized by substantial reduction in oxygen consumption, H+-movement and disappearance of acceptor control ratio. 2. When the substrate oxidized was succinate, depending on the 6-chloro-1,2,3-benzothiadiazole concn., little or no effect was observed on ADP phosphorylation and Ca2+-transport. 3. The results suggest that 6-chloro-1,2,3-benzothiadiazole can block site I at low concn., but at higher concn. can affect site I and site II, although site I is always more affected.

Original languageEnglish (US)
Pages (from-to)7-15
Number of pages9
JournalXenobiotica
Volume10
Issue number1
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Biochemistry, Genetics and Molecular Biology(all)

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