The 1-min sit-to-stand test in cystic fibrosis - Insights into cardiorespiratory responses

Thomas Radtke, Helge Hebestreit, Milo A. Puhan, Susi Kriemler

Research output: Contribution to journalArticlepeer-review


Background: We aimed to characterize the cardiopulmonary response during a 1-min sit-to-stand (STS) test and compare peak exercise cardiorespiratory variables to a maximal cardiopulmonary exercise test (CPET) in cystic fibrosis (CF). We further aimed to assess the validity of the STS power index (PowerSTS) as a measure of exercise capacity. Methods: Fifteen adult CF patients performed spirometry, CPET and the 1-min STS test with respiratory gas analysis. Results: Peak-exercise cardiorespiratory variables during the 1-min STS test correlated strongly (r =0.69-0.98) with those measured during the CPET. Oxygen uptake, carbon dioxide production, heart rate, ventilation, and tidal volume at peak exercise were 24%, 26%, 9%, 10% and 21% lower in the 1-min STS test, while respiratory frequencies were 14% higher. PowerSTS showed strong to very strong correlations with CPET-derived absolute peak oxygen uptake and maximal workload. Conclusions: The 1-min STS test elicits a substantial but lower cardiorespiratory response compared to a maximal cycle ergometry CPET. While PowerSTS and STS repetitions are both valid outcome measures of functional capacity, STS repetitions are clinically more practical.

Original languageEnglish (US)
JournalJournal of Cystic Fibrosis
StateAccepted/In press - Nov 28 2016


  • Exercise testing
  • Functional capacity
  • Lung disease
  • Validity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Fingerprint Dive into the research topics of 'The 1-min sit-to-stand test in cystic fibrosis - Insights into cardiorespiratory responses'. Together they form a unique fingerprint.

Cite this