The σ70-like motif: A eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis

Karen A. Wehner, Susan J. Baserga

Research output: Contribution to journalArticlepeer-review

Abstract

Little is understood about the role of nucleolar RNA binding proteins in ribosome biogenesis, although there is a clear need for them based on the strict folding requirements of the pre-rRNA. We have identified a superfamily of RNA binding proteins whose members are required for different stages of ribosome biogenesis. The Imp4 superfamily is composed of five individual families (Imp4, Rpf1, Rpf2, Brx1, and Ssf) that all possess the σ70-like motif, a eukaryotic RNA binding domain with prokaryotic origins. The Imp4 superfamily members associate with RNAs that are consistent with their distinct roles in ribosome biogenesis and suggest the mechanisms by which they function.

Original languageEnglish (US)
Pages (from-to)329-339
Number of pages11
JournalMolecular cell
Volume9
Issue number2
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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