Abstract
Interactions between δ-opioid receptors and morphine-preferring CL-opioid receptor subtypes have been suggested. Availability of transgenic μ-opioid receptor knockout mice allows assessment of μ-opioid receptor roles in the analgesia produced by the classical δ-opioid receptor agonist [D-Pen2,D-Pen5]enkephalin (DPDPE) in hot-plate and tail-flick tests. DPDPE analgesia was dramatically reduced in μ-opioid receptor knockout mice in a gene-dose-dependent fashion. The analgesia induced by this classic δ-opioid receptor agonist depends on intact μ-opioid receptors, suggesting that selective δ-opioid receptor drugs may require μ-opioid receptor occupancies for full efficacy.
| Original language | English (US) |
|---|---|
| Journal | European Journal of Pharmacology |
| Volume | 324 |
| Issue number | 2-3 |
| State | Published - Apr 1997 |
Keywords
- δ-Opioid receptor
- μ-Opioid receptor knockout mouse
- DPDPE ([D-Pen,D-Pen]enkephalin
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology