The ΔT thermal dose concept 1: In vivo teratogenesis

Morton W. Miller, Richard K. Miller, Linda F. Battaglia, William C. Dewey, Marsh J. Edwards, Wesley L. Nyborg, Christopher Cox, Jacques S. Abramowicz

Research output: Contribution to journalArticle

Abstract

This project was an initial test of the hypothesis that there would be a ΔT thermal dose relationship for birth defects in rats (Rattus norvegicus) during neural tube closure (NTC). Additionally, the same thermal dose as applied during NTC in utero in vivo, was also applied to exteriorized (i.e., ex vivo) in utero pregnant uterine horns at a comparable stage of organogenesis. Since the yields of the two regimens were comparable, the hyperthermia-induced teratogenic effects appear to result from the thermal dosing of the in utero embryos and not the elevated temperature of the mother. The hypothesis was supported.

Original languageEnglish (US)
Pages (from-to)141-149
Number of pages9
JournalJournal of Thermal Biology
Volume29
Issue number3
DOIs
StatePublished - Apr 2004
Externally publishedYes

Fingerprint

Teratogenesis
Neural Tube
Hot Temperature
heat
dosage
Induced Hyperthermia
Organogenesis
Rattus norvegicus
organogenesis
fever
Rats
Embryonic Structures
Defects
Temperature
rats
temperature
testing

Keywords

  • Birth defects
  • Mammalian cell lines
  • Maternal effects
  • Neural tube closure
  • Rats
  • Thermal dose

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

Miller, M. W., Miller, R. K., Battaglia, L. F., Dewey, W. C., Edwards, M. J., Nyborg, W. L., ... Abramowicz, J. S. (2004). The ΔT thermal dose concept 1: In vivo teratogenesis. Journal of Thermal Biology, 29(3), 141-149. https://doi.org/10.1016/j.jtherbio.2004.01.003

The ΔT thermal dose concept 1 : In vivo teratogenesis. / Miller, Morton W.; Miller, Richard K.; Battaglia, Linda F.; Dewey, William C.; Edwards, Marsh J.; Nyborg, Wesley L.; Cox, Christopher; Abramowicz, Jacques S.

In: Journal of Thermal Biology, Vol. 29, No. 3, 04.2004, p. 141-149.

Research output: Contribution to journalArticle

Miller, MW, Miller, RK, Battaglia, LF, Dewey, WC, Edwards, MJ, Nyborg, WL, Cox, C & Abramowicz, JS 2004, 'The ΔT thermal dose concept 1: In vivo teratogenesis', Journal of Thermal Biology, vol. 29, no. 3, pp. 141-149. https://doi.org/10.1016/j.jtherbio.2004.01.003
Miller MW, Miller RK, Battaglia LF, Dewey WC, Edwards MJ, Nyborg WL et al. The ΔT thermal dose concept 1: In vivo teratogenesis. Journal of Thermal Biology. 2004 Apr;29(3):141-149. https://doi.org/10.1016/j.jtherbio.2004.01.003
Miller, Morton W. ; Miller, Richard K. ; Battaglia, Linda F. ; Dewey, William C. ; Edwards, Marsh J. ; Nyborg, Wesley L. ; Cox, Christopher ; Abramowicz, Jacques S. / The ΔT thermal dose concept 1 : In vivo teratogenesis. In: Journal of Thermal Biology. 2004 ; Vol. 29, No. 3. pp. 141-149.
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