The β-amyloid-related proteins presenilin 1 and BACE1 are axonally transported to nerve terminals in the brain

Jin G. Sheng, Donald L. Price, Vassilis E. Koliatsos

Research output: Contribution to journalArticle

Abstract

In this study, we show that removal of entorhinal cortex (ERC) afferents to hippocampus reduces levels of presenilin 1 (PS1) in the dentate gyrus of APPswe/PS1ΔE9 transgenic (Tg) mice. PS1 immunoreactivity on the deafferented dentate gyrus decreases by approximately 25% and 50%, 2 and 4 weeks post-lesion compared to the contralateral side; by Western blotting, there is an approximately 40% decrease of the 43 kDa (full length) PS1 and an approximately 80% decrease of the 28 kDa (N-terminal fragment) PS1 on the lesioned dentate gyrus. Levels of β-site APP Cleavage Enzyme 1 (BACE1) immunoreactivity also decrease by approximately 50% and 65% 2 and 4 weeks post-lesion. Together, these data demonstrate that PS1 and BACE1 are transported from the entorhinal cortex to the hippocampus via axons of the perforant pathway.

Original languageEnglish (US)
Pages (from-to)1053-1057
Number of pages5
JournalExperimental Neurology
Volume184
Issue number2
DOIs
StatePublished - Dec 2003

Keywords

  • APP
  • Alzheimer disease
  • Amyloid
  • Axonal transport
  • Hippocampus
  • Perforant pathway
  • β-secretase

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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