The investigation of the occurrence of the α-effect in group transfers from phenyldialkyl sulfonium ions where one alkyl group is benzyl allows an assay of the effect of changing the nature of the C atom being transferred. The size of the α-effect responds to increasing electron demand, as methyl transfers do. Quantitative relationships between the size of the α-effect are established from both the nucleophilic side and the leaving group side of the S(N)2 transition state.
ASJC Scopus subject areas
- Organic Chemistry