The x-ray crystal structure of a mutant of staphylococcal nuclease that contains a single glycine residue inserted in the C-terminal α-helix has been solved to 1.67 Å resolution and refined to a crystallographic R value of 0.170. This inserted glycine residue is accommodated in the α-helix by formation of a previously uncharacterized bulge, which we term the α aneurism. A conformational search of known protein structures has identified the α aneurism in a number of protein families, including the histocompatibility antigens and hemoglobins.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|State||Published - Apr 15 1993|
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