The ΔT thermal dose concept 1: In vivo teratogenesis

Morton W. Miller; Richard K. Miller; Linda F. Battaglia; William C. Dewey; Marsh J. Edwards; Wesley L. Nyborg; Christopher Cox; Jacques S. Abramowicz

doi:10.1016/j.jtherbio.2004.01.003

The ΔT thermal dose concept 1: In vivo teratogenesis

Morton W. Miller, Richard K. Miller, Linda F. Battaglia, William C. Dewey, Marsh J. Edwards, Wesley L. Nyborg, Christopher Cox, Jacques S. Abramowicz

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

This project was an initial test of the hypothesis that there would be a ΔT thermal dose relationship for birth defects in rats (Rattus norvegicus) during neural tube closure (NTC). Additionally, the same thermal dose as applied during NTC in utero in vivo, was also applied to exteriorized (i.e., ex vivo) in utero pregnant uterine horns at a comparable stage of organogenesis. Since the yields of the two regimens were comparable, the hyperthermia-induced teratogenic effects appear to result from the thermal dosing of the in utero embryos and not the elevated temperature of the mother. The hypothesis was supported.

Original language	English (US)
Pages (from-to)	141-149
Number of pages	9
Journal	Journal of Thermal Biology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/j.jtherbio.2004.01.003
State	Published - Apr 2004
Externally published	Yes

Keywords

Birth defects
Mammalian cell lines
Maternal effects
Neural tube closure
Rats
Thermal dose

ASJC Scopus subject areas

Biochemistry
Physiology
General Agricultural and Biological Sciences
Developmental Biology

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10.1016/j.jtherbio.2004.01.003

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title = "The ΔT thermal dose concept 1: In vivo teratogenesis",

abstract = "This project was an initial test of the hypothesis that there would be a ΔT thermal dose relationship for birth defects in rats (Rattus norvegicus) during neural tube closure (NTC). Additionally, the same thermal dose as applied during NTC in utero in vivo, was also applied to exteriorized (i.e., ex vivo) in utero pregnant uterine horns at a comparable stage of organogenesis. Since the yields of the two regimens were comparable, the hyperthermia-induced teratogenic effects appear to result from the thermal dosing of the in utero embryos and not the elevated temperature of the mother. The hypothesis was supported.",

keywords = "Birth defects, Mammalian cell lines, Maternal effects, Neural tube closure, Rats, Thermal dose",

author = "Miller, {Morton W.} and Miller, {Richard K.} and Battaglia, {Linda F.} and Dewey, {William C.} and Edwards, {Marsh J.} and Nyborg, {Wesley L.} and Christopher Cox and Abramowicz, {Jacques S.}",

note = "Funding Information: Research supported by PHS NIH grants RO3HD37669-02, R37CA39230-28 and R37EB00213-28, and a grant from the Mae Stone Goode Foundation to MWM. The technical assistance of Ms. Teresa A. Sherman, Mrs. Elizabeth Ryan, and Dr. Mark A Plessinger greatly facilitated the conduct of this project. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2004",

month = apr,

doi = "10.1016/j.jtherbio.2004.01.003",

language = "English (US)",

volume = "29",

pages = "141--149",

journal = "Journal of Thermal Biology",

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publisher = "Elsevier Limited",

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T2 - In vivo teratogenesis

AU - Miller, Morton W.

AU - Miller, Richard K.

AU - Battaglia, Linda F.

AU - Dewey, William C.

AU - Edwards, Marsh J.

AU - Nyborg, Wesley L.

AU - Cox, Christopher

AU - Abramowicz, Jacques S.

N1 - Funding Information: Research supported by PHS NIH grants RO3HD37669-02, R37CA39230-28 and R37EB00213-28, and a grant from the Mae Stone Goode Foundation to MWM. The technical assistance of Ms. Teresa A. Sherman, Mrs. Elizabeth Ryan, and Dr. Mark A Plessinger greatly facilitated the conduct of this project. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2004/4

Y1 - 2004/4

N2 - This project was an initial test of the hypothesis that there would be a ΔT thermal dose relationship for birth defects in rats (Rattus norvegicus) during neural tube closure (NTC). Additionally, the same thermal dose as applied during NTC in utero in vivo, was also applied to exteriorized (i.e., ex vivo) in utero pregnant uterine horns at a comparable stage of organogenesis. Since the yields of the two regimens were comparable, the hyperthermia-induced teratogenic effects appear to result from the thermal dosing of the in utero embryos and not the elevated temperature of the mother. The hypothesis was supported.

AB - This project was an initial test of the hypothesis that there would be a ΔT thermal dose relationship for birth defects in rats (Rattus norvegicus) during neural tube closure (NTC). Additionally, the same thermal dose as applied during NTC in utero in vivo, was also applied to exteriorized (i.e., ex vivo) in utero pregnant uterine horns at a comparable stage of organogenesis. Since the yields of the two regimens were comparable, the hyperthermia-induced teratogenic effects appear to result from the thermal dosing of the in utero embryos and not the elevated temperature of the mother. The hypothesis was supported.

KW - Birth defects

KW - Mammalian cell lines

KW - Maternal effects

KW - Neural tube closure

KW - Rats

KW - Thermal dose

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SN - 0306-4565

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EP - 149

JO - Journal of Thermal Biology

JF - Journal of Thermal Biology

IS - 3

ER -

The ΔT thermal dose concept 1: In vivo teratogenesis

Abstract

Keywords

ASJC Scopus subject areas

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