Thalidomide for acute treatment of neurosarcoidosis

E. R. Hammond, Adam I Kaplin, D. A. Kerr

Research output: Contribution to journalArticle

Abstract

Study design: Case report. Clinical setting: Johns Hopkins University School of Medicine, Baltimore, MD, USA. Case report: Sarcoidosis is a multi-system granulomatous disease of unknown etiology with worldwide distribution. The involvement of the nervous system is common - neurosarcoidosis. Immune responses play an important role in the inflammatory process and granuloma formation. We report a case of neurosarcoidosis that was refractory to two courses of intravenous steroids. Upon initiation of oral thalidomide, the patient showed dramatic improvement clinically and on magnetic resonance imaging. Conclusion: Thalidomide is an immunomodulatory agent that acts to inhibit production of tumor-necrosis factor-α (TNF-α), an important mediator in CNS inflammation, by enhancing TNF-α mRNA degradation. Corticosteroids have been the mainstay of treatment of neurosarcoidosis with success at halting progression of the immune process in 50% cases. Thalidomide offers unique opportunities at managing CNS inflammation due to neurosarcoidosis. Disclosures: None.

Original languageEnglish (US)
Pages (from-to)802-803
Number of pages2
JournalSpinal Cord
Volume45
Issue number12
DOIs
StatePublished - Dec 2007

Fingerprint

Thalidomide
Tumor Necrosis Factor-alpha
Inflammation
Baltimore
RNA Stability
Disclosure
Therapeutics
Sarcoidosis
Granuloma
Nervous System
Adrenal Cortex Hormones
Steroids
Magnetic Resonance Imaging
Medicine
Neurosarcoidosis

Keywords

  • Immunotherapy
  • Neurosarcoidosis
  • Thalidomide

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Thalidomide for acute treatment of neurosarcoidosis. / Hammond, E. R.; Kaplin, Adam I; Kerr, D. A.

In: Spinal Cord, Vol. 45, No. 12, 12.2007, p. 802-803.

Research output: Contribution to journalArticle

Hammond, E. R. ; Kaplin, Adam I ; Kerr, D. A. / Thalidomide for acute treatment of neurosarcoidosis. In: Spinal Cord. 2007 ; Vol. 45, No. 12. pp. 802-803.
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