Thalamus and posterior temporal lobe show greater inter-network connectivity at rest and across sensory paradigms in schizophrenia

Mustafa S. Çetin, Fletcher Christensen, Christopher C. Abbott, Julia M. Stephen, Andrew R. Mayer, José M. Cañive, Juan R. Bustillo, Godfrey D. Pearlson, Vince D. Calhoun

Research output: Contribution to journalArticlepeer-review


Although a number of recent studies have examined functional connectivity at rest, few have assessed differences between connectivity both during rest and across active task paradigms. Therefore, the question of whether cortical connectivity patterns remain stable or change with task engagement continues to be unaddressed. We collected multi-scan fMRI data on healthy controls (N= 53) and schizophrenia patients (N= 42) during rest and across paradigms arranged hierarchically by sensory load. We measured functional network connectivity among 45 non-artifactual distinct brain networks. Then, we applied a novel analysis to assess cross paradigm connectivity patterns applied to healthy controls and patients with schizophrenia. To detect these patterns, we fit a group by task full factorial ANOVA model to the group average functional network connectivity values. Our approach identified both stable (static effects) and state-based differences (dynamic effects) in brain connectivity providing a better understanding of how individuals' reactions to simple sensory stimuli are conditioned by the context within which they are presented. Our findings suggest that not all group differences observed during rest are detectable in other cognitive states. In addition, the stable differences of heightened connectivity between multiple brain areas with thalamus across tasks underscore the importance of the thalamus as a gateway to sensory input and provide new insight into schizophrenia.

Original languageEnglish (US)
Pages (from-to)117-126
Number of pages10
StatePublished - Aug 15 2014
Externally publishedYes


  • Connectivity
  • FMRI
  • Posterior temporal areas
  • Schizophrenia
  • Static & dynamic connectivity
  • Thalamus

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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