Thalamic single-unit activity occurring in patients with hemidystonia

Frederick Lenz, R. Martin, H. C. Kwan, R. R. Tasker, J. O. Dostrovsky

Research output: Contribution to journalArticle

Abstract

Lesions of the ventrolateral complex of the human thalamus may relieve abnormal movements in patients with dystonia. We have now recorded the thalamic single-unit activity and the electromyographic (EMG) activity in the upper extremity during the physiologic localization which is required prior to thalamotomy for hemidystonia. The activity of thalamic single units was correlated with the EMG signal by spectral methods. Results of this analysis indicate that a group of thalamic cells show a concentration of activity, occurring at the same frequency as the EMG activity during dystonia. In many cases, there was statistically significant correlation between thalamic and EMG signals at the frequency of dystonia. The activity of these cells may be involved in the generation of dystonic movements.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalStereotactic and Functional Neurosurgery
Volume54
Issue number1-8
DOIs
StatePublished - 1990

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Dystonia
Dyskinesias
Thalamus
Upper Extremity

Keywords

  • Cross-correlation analysis
  • Dystonia
  • Sensorimotor integration
  • Stroke
  • Thalamus single-unit analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

Cite this

Thalamic single-unit activity occurring in patients with hemidystonia. / Lenz, Frederick; Martin, R.; Kwan, H. C.; Tasker, R. R.; Dostrovsky, J. O.

In: Stereotactic and Functional Neurosurgery, Vol. 54, No. 1-8, 1990, p. 159-162.

Research output: Contribution to journalArticle

Lenz, Frederick ; Martin, R. ; Kwan, H. C. ; Tasker, R. R. ; Dostrovsky, J. O. / Thalamic single-unit activity occurring in patients with hemidystonia. In: Stereotactic and Functional Neurosurgery. 1990 ; Vol. 54, No. 1-8. pp. 159-162.
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