Thalamic post-inhibitory bursting occurs in patients with organic dystonia more often than controls

K. Kobayashi, C. C. Liu, A. L. Jensen, J. L. Vitek, Z. Mari, Frederick Lenz

Research output: Contribution to journalArticle

Abstract

We now test the hypothesis that post-inhibitory bursting in the human pallidal receiving nucleus of the thalamus (ventral oral) mediates inhibitory pallido-thalamic transmission during dystonia. We have compared thalamic single neuron activity in nine patients with organic dystonia to that in a patient with psychogenic dystonia (Psyd) and in healthy waking monkeys. In organic dystonia, EMG power is commonly concentrated at the lowest frequency of the smoothed autopower spectrum (0.39 Hz). Therefore, segments of spike trains with a signal-to-noise ratio ≥2 at 0.39 Hz were termed dystonia frequency (DF) segments, which occurred more commonly during dystonia related to movement. Those with a SNR

Original languageEnglish (US)
Pages (from-to)81-91
Number of pages11
JournalBrain Research
Volume1541
DOIs
StatePublished - Dec 6 2013

Fingerprint

Dystonia
Ventral Thalamic Nuclei
Dystonic Disorders
Signal-To-Noise Ratio
Haplorhini
Neurons

Keywords

  • Dystonia
  • Low threshold spike burst
  • Single neuron analysis
  • Thalamotomy
  • Thalamus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Thalamic post-inhibitory bursting occurs in patients with organic dystonia more often than controls. / Kobayashi, K.; Liu, C. C.; Jensen, A. L.; Vitek, J. L.; Mari, Z.; Lenz, Frederick.

In: Brain Research, Vol. 1541, 06.12.2013, p. 81-91.

Research output: Contribution to journalArticle

Kobayashi, K. ; Liu, C. C. ; Jensen, A. L. ; Vitek, J. L. ; Mari, Z. ; Lenz, Frederick. / Thalamic post-inhibitory bursting occurs in patients with organic dystonia more often than controls. In: Brain Research. 2013 ; Vol. 1541. pp. 81-91.
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