Thalamic parcellation from multi-modal data using random forest learning

Joshua V. Stough, Chuyang Ye, Sarah H. Ying, Jerry L. Prince

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The thalamus sub-cortical gray matter structure consists of contiguous nuclei, each individually responsible for communication between various cerebral cortex and midbrain regions. These nuclei are differentially affected in neurodegenerative diseases such as multiple sclerosis and Alzheimer's. However thalamic parcellation of the nuclei, manual or automatic, is difficult given the limited contrast in any particular magnetic resonance (MR) modality. Several groups have had qualitative success differentiating nuclei based on spatial location and fiber orientation information in diffusion tensor imaging (DTI). In this paper, we extend these principles by combining these discriminating dimensions with structural MR and derived information, and by building random forest learners on the resultant multi-modal features. In training, we form a multi-dimensional feature per voxel, which we associate with a nucleus classification from a manual rater. Learners are trained to differentiate thalamus from background and thalamic nuclei from other nuclei. These learners inform the external forces of a multiple object level set model. Our cross-validated quantitative results on a set of twenty subjects show the efficacy and reproducibility of our results.

Original languageEnglish (US)
Title of host publicationISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging
Subtitle of host publicationFrom Nano to Macro
Pages852-855
Number of pages4
DOIs
StatePublished - Aug 22 2013
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: Apr 7 2013Apr 11 2013

Publication series

NameProceedings - International Symposium on Biomedical Imaging
ISSN (Print)1945-7928
ISSN (Electronic)1945-8452

Other

Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
CountryUnited States
CitySan Francisco, CA
Period4/7/134/11/13

Keywords

  • Diffusion tensor imaging
  • deformable models
  • machine learning
  • object segmentation
  • random forests

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Thalamic parcellation from multi-modal data using random forest learning'. Together they form a unique fingerprint.

  • Cite this

    Stough, J. V., Ye, C., Ying, S. H., & Prince, J. L. (2013). Thalamic parcellation from multi-modal data using random forest learning. In ISBI 2013 - 2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro (pp. 852-855). [6556609] (Proceedings - International Symposium on Biomedical Imaging). https://doi.org/10.1109/ISBI.2013.6556609