Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers

Zaiyang Long, Xiang Rong Li, Jun Xu, Richard Anthony Edward Edden, Wei Ping Qin, Li Ling Long, James B. Murdoch, Wei Zheng, Yue Ming Jiang, Ulrike Dydak

Research output: Contribution to journalArticle

Abstract

Overexposure to manganese (Mn) may lead to parkinsonian symptoms including motor deficits. The main inhibitory neurotransmitter gamma-aminobutyric acid (GABA) is known to play a pivotal role in the regulation and performance of movement. Therefore this study was aimed at testing the hypothesis that an alteration of GABA following Mn exposure may be associated with fine motor performance in occupationally exposed workers and may underlie the mechanism of Mn-induced motor deficits. A cohort of nine Mn-exposed male smelter workers from an Mn-iron alloy factory and 23 gender-and age-matched controls were recruited and underwent neurological exams, magnetic resonance spectroscopy (MRS) measurements, and Purdue pegboard motor testing. Short-echo-time MRS was used to measure N-Acetyl-aspartate (NAA) and myo-inositol (mI). GABA was detected with a MEGA-PRESS J-editing MRS sequence. The mean thalamic GABA level was significantly increased in smelter workers compared to controls (p = 0.009). Multiple linear regression analysis reveals (1) a significant association between the increase in GABA level and the duration of exposure (R2 = 0.660, p = 0.039), and (2) significant inverse associations between GABA levels and all Purdue pegboard test scores (for summation of all scores R2 = 0.902, p = 0.001) in the smelter workers. In addition, levels of mI were reduced significantly in the thalamus and PCC of smelter workers compared to controls (p = 0.030 and p = 0.009, respectively). In conclusion, our results show clear associations between thalamic GABA levels and fine motor performance. Thus in Mn-exposed subjects, increased thalamic GABA levels may serve as a biomarker for subtle deficits in motor control and may become valuable for early diagnosis of Mn poisoning.

Original languageEnglish (US)
Article numbere88220
JournalPLoS One
Volume9
Issue number2
DOIs
StatePublished - Feb 4 2014

Fingerprint

gamma-aminobutyric acid
Manganese
gamma-Aminobutyric Acid
manganese
Magnetic resonance spectroscopy
spectroscopy
Magnetic Resonance Spectroscopy
Inositol
myo-inositol
Manganese Poisoning
thalamus
early diagnosis
testing
Testing
Biomarkers
aspartic acid
neurotransmitters
Thalamus
factories
Linear regression

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers. / Long, Zaiyang; Li, Xiang Rong; Xu, Jun; Edden, Richard Anthony Edward; Qin, Wei Ping; Long, Li Ling; Murdoch, James B.; Zheng, Wei; Jiang, Yue Ming; Dydak, Ulrike.

In: PLoS One, Vol. 9, No. 2, e88220, 04.02.2014.

Research output: Contribution to journalArticle

Long, Z, Li, XR, Xu, J, Edden, RAE, Qin, WP, Long, LL, Murdoch, JB, Zheng, W, Jiang, YM & Dydak, U 2014, 'Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers', PLoS One, vol. 9, no. 2, e88220. https://doi.org/10.1371/journal.pone.0088220
Long, Zaiyang ; Li, Xiang Rong ; Xu, Jun ; Edden, Richard Anthony Edward ; Qin, Wei Ping ; Long, Li Ling ; Murdoch, James B. ; Zheng, Wei ; Jiang, Yue Ming ; Dydak, Ulrike. / Thalamic GABA predicts fine motor performance in manganese-exposed smelter workers. In: PLoS One. 2014 ; Vol. 9, No. 2.
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