Thalamic fractional anisotropy predicts accrual of cerebral white matter damage in older subjects with small-vessel disease

Michele Cavallari, Nicola Moscufo, Dominik Meier, Pawel Skudlarski, Godfrey D. Pearlson, William B. White, Leslie Wolfson, Charles R.G. Guttmann

    Research output: Contribution to journalArticlepeer-review

    Abstract

    White matter hyperintensities (WMHs) and lacunes are magnetic resonance imaging hallmarks of cerebral small-vessel disease, which increase the risk of stroke, cognitive, and mobility impairment. Although most studies of cerebral small-vessel disease have focused on white matter abnormalities, the gray matter (GM) is also affected, as evidenced by frequently observed lacunes in subcortical GM. Diffusion tensor imaging (DTI) is sensitive to subtle neurodegenerative changes in deep GM structures. We explored the relationship between baseline DTI characteristics of the thalamus, caudate, and putamen, and the volume and subsequent accrual of WMHs over a 4-year period in 56 community-dwelling older (≥75 years) individuals. Baseline thalamic fractional anisotropy (FA) was an independent predictor of WMH accrual. WMH accrual also correlated with baseline lacune count and baseline WMH volume, the latter showing the strongest predictive power, explaining 27.3% of the variance. The addition of baseline thalamic FA in multivariate modeling increased this value by 70%, which explains 46.5% of the variance in WMH accrual rate. Thalamic FA might serve as a novel predictor of cerebral small-vessel disease progression in clinical settings and trials. Furthermore, our findings point to the possibility of a causal relationship between thalamic damage and the accrual of WMHs.

    Original languageEnglish (US)
    Pages (from-to)1321-1327
    Number of pages7
    JournalJournal of Cerebral Blood Flow and Metabolism
    Volume34
    Issue number8
    DOIs
    StatePublished - Aug 2014

    Keywords

    • aging
    • deep gray matter
    • diffusion tensor imaging
    • magnetic resonance imaging
    • small-vessel disease
    • white matter hyperintensities

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology
    • Cardiology and Cardiovascular Medicine

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