TGF-β family signaling in connective tissue and skeletal diseases

Elena MacFarlane, Julia Haupt, Harry C Dietz, Eileen M. Shore

Research output: Contribution to journalReview article

Abstract

The transforming growth factor b (TGF-β) family of signaling molecules, which includes TGF-βs, activins, inhibins, and numerous bone morphogenetic proteins (BMPs) and growth and differentiation factors (GDFs), has important functions in all cells and tissues, including soft connective tissues and the skeleton. Specific TGF-β family members play different roles in these tissues, and their activities are often balanced with those of other TGF-β family members and by interactions with other signaling pathways. Perturbations in TGF-β family pathways are associated with numerous human diseases with prominent involvement of the skeletal and cardiovascular systems. This review focuses on the role of this family of signaling molecules in the pathologies of connective tissues that manifest in rare genetic syndromes (e.g., syndromic presentations of thoracic aortic aneurysm), as well as in more common disorders (e.g., osteoarthritis and osteoporosis). Many of these diseases are caused by or result in pathological alterations of the complex relationship between the TGF-β family of signaling mediators and the extracellular matrix in connective tissues.

Original languageEnglish (US)
Article numbera022269
JournalCold Spring Harbor perspectives in biology
Volume9
Issue number11
DOIs
StatePublished - Nov 1 2017

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Connective Tissue Diseases
Transforming Growth Factors
Tissue
Connective Tissue
Growth Differentiation Factors
Thoracic Aortic Aneurysm
Cardiovascular system
Activins
Inhibins
Bone Morphogenetic Proteins
Molecules
Pathology
Cardiovascular System
Skeleton
Osteoarthritis
Osteoporosis
Extracellular Matrix

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

TGF-β family signaling in connective tissue and skeletal diseases. / MacFarlane, Elena; Haupt, Julia; Dietz, Harry C; Shore, Eileen M.

In: Cold Spring Harbor perspectives in biology, Vol. 9, No. 11, a022269, 01.11.2017.

Research output: Contribution to journalReview article

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