TGFβ signals through a heteromeric protein kinase receptor complex

Jeffrey L. Wrana, Liliana Attisano, Juan Cárcamo, Alejandro Zentella, Jacqueline Doody, Marikki Laiho, Xiao Fan Wang, Joan Massague

Research output: Contribution to journalArticle

Abstract

Transforming growth factor β (TGFβ) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFβ-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGFβ, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.

Original languageEnglish (US)
Pages (from-to)1003-1014
Number of pages12
JournalCell
Volume71
Issue number6
DOIs
StatePublished - Dec 11 1992
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Wrana, J. L., Attisano, L., Cárcamo, J., Zentella, A., Doody, J., Laiho, M., Wang, X. F., & Massague, J. (1992). TGFβ signals through a heteromeric protein kinase receptor complex. Cell, 71(6), 1003-1014. https://doi.org/10.1016/0092-8674(92)90395-S