TGFβ signals through a heteromeric protein kinase receptor complex

Jeffrey L. Wrana, Liliana Attisano, Juan Cárcamo, Alejandro Zentella, Jacqueline Doody, Marikki Laiho, Xiao Fan Wang, Joan Massague

Research output: Contribution to journalArticle

Abstract

Transforming growth factor β (TGFβ) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFβ-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGFβ, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.

Original languageEnglish (US)
Pages (from-to)1003-1014
Number of pages12
JournalCell
Volume71
Issue number6
DOIs
StatePublished - Dec 11 1992
Externally publishedYes

Fingerprint

Transforming Growth Factors
Protein Kinases
Receptor Protein-Tyrosine Kinases
Cytokine Receptors
Growth Factor Receptors
Protein-Serine-Threonine Kinases
Carrier Proteins
Phosphotransferases
Genes
Growth
Proteins

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Wrana, J. L., Attisano, L., Cárcamo, J., Zentella, A., Doody, J., Laiho, M., ... Massague, J. (1992). TGFβ signals through a heteromeric protein kinase receptor complex. Cell, 71(6), 1003-1014. https://doi.org/10.1016/0092-8674(92)90395-S

TGFβ signals through a heteromeric protein kinase receptor complex. / Wrana, Jeffrey L.; Attisano, Liliana; Cárcamo, Juan; Zentella, Alejandro; Doody, Jacqueline; Laiho, Marikki; Wang, Xiao Fan; Massague, Joan.

In: Cell, Vol. 71, No. 6, 11.12.1992, p. 1003-1014.

Research output: Contribution to journalArticle

Wrana, JL, Attisano, L, Cárcamo, J, Zentella, A, Doody, J, Laiho, M, Wang, XF & Massague, J 1992, 'TGFβ signals through a heteromeric protein kinase receptor complex', Cell, vol. 71, no. 6, pp. 1003-1014. https://doi.org/10.1016/0092-8674(92)90395-S
Wrana JL, Attisano L, Cárcamo J, Zentella A, Doody J, Laiho M et al. TGFβ signals through a heteromeric protein kinase receptor complex. Cell. 1992 Dec 11;71(6):1003-1014. https://doi.org/10.1016/0092-8674(92)90395-S
Wrana, Jeffrey L. ; Attisano, Liliana ; Cárcamo, Juan ; Zentella, Alejandro ; Doody, Jacqueline ; Laiho, Marikki ; Wang, Xiao Fan ; Massague, Joan. / TGFβ signals through a heteromeric protein kinase receptor complex. In: Cell. 1992 ; Vol. 71, No. 6. pp. 1003-1014.
@article{30dcec4ec92a4f03b51589e68359a4a5,
title = "TGFβ signals through a heteromeric protein kinase receptor complex",
abstract = "Transforming growth factor β (TGFβ) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFβ-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGFβ, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.",
author = "Wrana, {Jeffrey L.} and Liliana Attisano and Juan C{\'a}rcamo and Alejandro Zentella and Jacqueline Doody and Marikki Laiho and Wang, {Xiao Fan} and Joan Massague",
year = "1992",
month = "12",
day = "11",
doi = "10.1016/0092-8674(92)90395-S",
language = "English (US)",
volume = "71",
pages = "1003--1014",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - TGFβ signals through a heteromeric protein kinase receptor complex

AU - Wrana, Jeffrey L.

AU - Attisano, Liliana

AU - Cárcamo, Juan

AU - Zentella, Alejandro

AU - Doody, Jacqueline

AU - Laiho, Marikki

AU - Wang, Xiao Fan

AU - Massague, Joan

PY - 1992/12/11

Y1 - 1992/12/11

N2 - Transforming growth factor β (TGFβ) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFβ-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGFβ, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.

AB - Transforming growth factor β (TGFβ) binds with high affinity to the type II receptor, a transmembrane protein with a cytoplasmic serine/threonine kinase domain. We show that the type II receptor requires both its kinase activity and association with another TGFβ-binding protein, the type I receptor, to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGFβ, and receptor II requires receptor I to signal. This mode of operation points to fundamental differences between this receptor and the protein-tyrosine kinase cytokine receptors.

UR - http://www.scopus.com/inward/record.url?scp=0026496172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026496172&partnerID=8YFLogxK

U2 - 10.1016/0092-8674(92)90395-S

DO - 10.1016/0092-8674(92)90395-S

M3 - Article

C2 - 1333888

AN - SCOPUS:0026496172

VL - 71

SP - 1003

EP - 1014

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -