Text2PreventCVD: Protocol for a systematic review and individual participant data meta-analysis of text message-based interventions for the prevention of cardiovascular diseases

Clara K. Chow, Sheikh Mohammed Shariful Islam, Andrew Farmer, Kirsty Bobrow, Ralph Maddision, Robyn Whittaker, Leila Pfaeffli Dale, Andreas Lechner, Louis Niessen, Scott A. Lear, Zubin J. Eapen, Karla Santo, Sandrine Stepien, Julie Redfern, Anthony Rodgers

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction Text message interventions have been shown to be effective in prevention and management of several non-communicable disease risk factors. However, the extent to which their effects might vary in different participants and settings is uncertain. We aim to conduct a systematic review and individual participant data (IPD) meta-analysis of randomised clinical trials examining text message interventions aimed to prevent cardiovascular diseases (CVD) through modification of cardiovascular risk factors (CVRFs). Methods and analysis Systematic review and IPD meta-analysis will be conducted according to Preferred Reporting Items for Systematic review and Meta-Analysis of IPD (PRISMA-IPD) guidelines. Electronic database of published studies (MEDLINE, EMBASE, PsycINFO and Cochrane Library) and international trial registries will be searched to identify relevant randomised clinical trials. Authors of studies meeting the inclusion criteria will be invited to join the IPD meta-analysis group and contribute study data to the common database. The primary outcome will be the difference between intervention and control groups in blood pressure at 6-month follow-up. Key secondary outcomes include effects on lipid parameters, body mass index, smoking levels and self-reported quality of life. If sufficient data is available, we will also analyse blood pressure and other secondary outcomes at 12 months. IPD meta-analysis will be performed using a one-step approach and modelling data simultaneously while accounting for the clustering of the participants within studies. This study will use the existing data to assess the effectiveness of text message-based interventions on CVRFs, the consistency of any effects by participant subgroups and across different healthcare settings. Ethics and dissemination Ethical approval was obtained for the individual studies by the trial investigators from relevant local ethics committees. This study will include anonymised data for secondary analysis and investigators will be asked to check that this is consistent with their existing approvals. Results will be disseminated via scientific forums including peer-reviewed publications and presentations at international conferences.

Original languageEnglish (US)
Article number012723
JournalBMJ open
Volume6
Issue number10
DOIs
StatePublished - Oct 1 2016

Keywords

  • Cardiovascular diseases
  • prevention
  • randomized controlled trials
  • short message service (SMS)
  • text messages

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Text2PreventCVD: Protocol for a systematic review and individual participant data meta-analysis of text message-based interventions for the prevention of cardiovascular diseases'. Together they form a unique fingerprint.

Cite this