Tetrasomy 21 in an infant with Down syndrome and congenital leukemia

E. W. Jabs, J. Stamberg, C. O. Leonard

Research output: Contribution to journalArticle

Abstract

A prematurely born infant with the manifestations of Down syndrome and congenital monocytic leukemia was found, by Q and R banding, to have the karyotype 48,XY,+21,+21. This appears to be the first case of tetrasomy 21 documented by banding. Clinically, the infant was indistinguishable from trisomic Down syndrome patients. He died at 4 days of respiratory insufficiency owing to hyaline membrane disease and E coli septicemia.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume12
Issue number1
StatePublished - 1982

ASJC Scopus subject areas

  • Genetics(clinical)

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