Tetrasomy 21 in an infant with Down syndrome and congenital leukemia

E. W. Jabs, J. Stamberg, C. O. Leonard

Research output: Contribution to journalArticle

Abstract

A prematurely born infant with the manifestations of Down syndrome and congenital monocytic leukemia was found, by Q and R banding, to have the karyotype 48,XY,+21,+21. This appears to be the first case of tetrasomy 21 documented by banding. Clinically, the infant was indistinguishable from trisomic Down syndrome patients. He died at 4 days of respiratory insufficiency owing to hyaline membrane disease and E coli septicemia.

Original languageEnglish (US)
Pages (from-to)91-95
Number of pages5
JournalAmerican Journal of Medical Genetics
Volume12
Issue number1
StatePublished - 1982

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Tetrasomy
Down Syndrome
Leukemia
Hyaline Membrane Disease
Karyotype
Respiratory Insufficiency
Sepsis
Escherichia coli

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Jabs, E. W., Stamberg, J., & Leonard, C. O. (1982). Tetrasomy 21 in an infant with Down syndrome and congenital leukemia. American Journal of Medical Genetics, 12(1), 91-95.

Tetrasomy 21 in an infant with Down syndrome and congenital leukemia. / Jabs, E. W.; Stamberg, J.; Leonard, C. O.

In: American Journal of Medical Genetics, Vol. 12, No. 1, 1982, p. 91-95.

Research output: Contribution to journalArticle

Jabs, EW, Stamberg, J & Leonard, CO 1982, 'Tetrasomy 21 in an infant with Down syndrome and congenital leukemia', American Journal of Medical Genetics, vol. 12, no. 1, pp. 91-95.
Jabs, E. W. ; Stamberg, J. ; Leonard, C. O. / Tetrasomy 21 in an infant with Down syndrome and congenital leukemia. In: American Journal of Medical Genetics. 1982 ; Vol. 12, No. 1. pp. 91-95.
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