TY - JOUR
T1 - Tetrasomy 21 in an infant with Down syndrome and congenital leukemia
AU - Jabs, E. W.
AU - Stamberg, J.
AU - Leonard, C. O.
PY - 1982
Y1 - 1982
N2 - A prematurely born infant with the manifestations of Down syndrome and congenital monocytic leukemia was found, by Q and R banding, to have the karyotype 48,XY,+21,+21. This appears to be the first case of tetrasomy 21 documented by banding. Clinically, the infant was indistinguishable from trisomic Down syndrome patients. He died at 4 days of respiratory insufficiency owing to hyaline membrane disease and E coli septicemia.
AB - A prematurely born infant with the manifestations of Down syndrome and congenital monocytic leukemia was found, by Q and R banding, to have the karyotype 48,XY,+21,+21. This appears to be the first case of tetrasomy 21 documented by banding. Clinically, the infant was indistinguishable from trisomic Down syndrome patients. He died at 4 days of respiratory insufficiency owing to hyaline membrane disease and E coli septicemia.
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M3 - Article
C2 - 6211984
AN - SCOPUS:0020032233
VL - 12
SP - 91
EP - 95
JO - American Journal of Medical Genetics, Part A
JF - American Journal of Medical Genetics, Part A
SN - 1552-4825
IS - 1
ER -