Tetrahydrobiopterin attenuates ischemiareperfusion injury following organ transplantation by targeting the nitric oxide synthase: Investigations in an animal model

Benno Cardini, Rupert Oberhuber, Sven R. Hein, Katrin Watschinger, Martin Hermann, Peter Obrist, Gabriele Werner-Felmayer, Gerald Brandacher, Johann Pratschke, Ernst R. Werner, Manuel Maglione

Research output: Contribution to journalArticle

Abstract

Ischemia-reperfusion injury is a primarily nonallospecific event leading to the depletion of the essential nitric oxide synthase cofactor and potent antioxidant tetrahydrobiopterin. Suboptimal concentrations of tetrahydrobiopterin result in a reduced biosynthesis of nitric oxide leading to vascular endothelial dysfunction. Tetrahydrobiopterin supplementation has been shown to protect from this pathological state in a plethora of cardiovascular diseases including transplant-related ischemia-reperfusion injury. Even though still controversially discussed, there is increasing evidence emerging from both human as well as animal studies that tetrahydrobiopterin-mediated actions rely on its nitric oxide synthase cofactor activity rather than on its antioxidative properties. Herein, we review the current literature regarding the role of tetrahydrobiopterin in ischemia-reperfusion injury including our experience acquired in a murine pancreas transplantation model.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalPteridines
Volume24
Issue number1
DOIs
StatePublished - Jun 2013

Fingerprint

Transplantation (surgical)
Organ Transplantation
Nitric Oxide Synthase
Animals
Animal Models
Reperfusion Injury
Wounds and Injuries
Pancreas Transplantation
Transplants
Biosynthesis
Blood Vessels
Nitric Oxide
Cardiovascular Diseases
Antioxidants
sapropterin

Keywords

  • Animal model
  • Ischemia-reperfusion injury
  • Nitric oxide
  • Organ transplantation
  • Tetrahydrobiopterin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Tetrahydrobiopterin attenuates ischemiareperfusion injury following organ transplantation by targeting the nitric oxide synthase : Investigations in an animal model. / Cardini, Benno; Oberhuber, Rupert; Hein, Sven R.; Watschinger, Katrin; Hermann, Martin; Obrist, Peter; Werner-Felmayer, Gabriele; Brandacher, Gerald; Pratschke, Johann; Werner, Ernst R.; Maglione, Manuel.

In: Pteridines, Vol. 24, No. 1, 06.2013, p. 13-19.

Research output: Contribution to journalArticle

Cardini, B, Oberhuber, R, Hein, SR, Watschinger, K, Hermann, M, Obrist, P, Werner-Felmayer, G, Brandacher, G, Pratschke, J, Werner, ER & Maglione, M 2013, 'Tetrahydrobiopterin attenuates ischemiareperfusion injury following organ transplantation by targeting the nitric oxide synthase: Investigations in an animal model', Pteridines, vol. 24, no. 1, pp. 13-19. https://doi.org/10.1515/pterid-2013-0006
Cardini, Benno ; Oberhuber, Rupert ; Hein, Sven R. ; Watschinger, Katrin ; Hermann, Martin ; Obrist, Peter ; Werner-Felmayer, Gabriele ; Brandacher, Gerald ; Pratschke, Johann ; Werner, Ernst R. ; Maglione, Manuel. / Tetrahydrobiopterin attenuates ischemiareperfusion injury following organ transplantation by targeting the nitric oxide synthase : Investigations in an animal model. In: Pteridines. 2013 ; Vol. 24, No. 1. pp. 13-19.
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