Tetradifon: An oligomycin-like inhibitor of energy-linked activities of rat liver mitochondria

Ernesto Bustamante, Peter L. Pedersen

Research output: Contribution to journalArticle

Abstract

Tetradifon (p-chlorophenyl-2,4,5-trichlorophenyl sulfone) at concentrations between 4.5 and 27.0 nmoles/mg mitochondrial protein provides half-maximal inhibition of the following energy-linked activities of rat liver mitochondria: ADP-stimulated respiration, DNP-stimulated ATPase activity, Mg++-stimulated ATPase activity, and Pi-ATP exchange activity. Tetradifon has no effect on the activity of soluble ATPase purified from rat liver mitochondria. Respiration inhibited by tetradifon is restored upon addition of 2,4-dinitrophenol. It is concluded that tetradifon acts at or near the oligomycin sensitivity conferring complex located in the mitochondrial inner membrane.

Original languageEnglish (US)
Pages (from-to)292-298
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume51
Issue number2
DOIs
StatePublished - Mar 19 1973

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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