Tetanus toxin: Direct evidence for retrograde intraaxonal transport

Donald L. Price; Jack Griffin; Ann Young; Keith Peck; Adelaine Stocks

doi:10.1126/science.49080

Tetanus toxin: Direct evidence for retrograde intraaxonal transport

Donald L. Price, Jack Griffin, Ann Young, Keith Peck, Adelaine Stocks

School of Medicine

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159 Scopus citations

Abstract

The neurotoxin tetanospasmin causes tetanus when it reaches the central nervous system. In this autoradiographic study, ¹²⁵I-labeled tetanospasmin was injected into the leg muscles of rodents, and the nerves supplying these muscles were crushed. The labeled toxin accumulated within axons on the distal side of the crush. This study provides direct evidence for retrograde axonal transport of a macromolecular toxin that acts at synapses in the central nervous system.

Original language	English (US)
Pages (from-to)	945-947
Number of pages	3
Journal	Science
Volume	188
Issue number	4191
DOIs	https://doi.org/10.1126/science.49080
State	Published - 1975

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title = "Tetanus toxin: Direct evidence for retrograde intraaxonal transport",

abstract = "The neurotoxin tetanospasmin causes tetanus when it reaches the central nervous system. In this autoradiographic study, 125I-labeled tetanospasmin was injected into the leg muscles of rodents, and the nerves supplying these muscles were crushed. The labeled toxin accumulated within axons on the distal side of the crush. This study provides direct evidence for retrograde axonal transport of a macromolecular toxin that acts at synapses in the central nervous system.",

author = "Price, {Donald L.} and Jack Griffin and Ann Young and Keith Peck and Adelaine Stocks",

year = "1975",

doi = "10.1126/science.49080",

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T2 - Direct evidence for retrograde intraaxonal transport

AU - Price, Donald L.

AU - Griffin, Jack

AU - Young, Ann

AU - Peck, Keith

AU - Stocks, Adelaine

PY - 1975

Y1 - 1975

N2 - The neurotoxin tetanospasmin causes tetanus when it reaches the central nervous system. In this autoradiographic study, 125I-labeled tetanospasmin was injected into the leg muscles of rodents, and the nerves supplying these muscles were crushed. The labeled toxin accumulated within axons on the distal side of the crush. This study provides direct evidence for retrograde axonal transport of a macromolecular toxin that acts at synapses in the central nervous system.

AB - The neurotoxin tetanospasmin causes tetanus when it reaches the central nervous system. In this autoradiographic study, 125I-labeled tetanospasmin was injected into the leg muscles of rodents, and the nerves supplying these muscles were crushed. The labeled toxin accumulated within axons on the distal side of the crush. This study provides direct evidence for retrograde axonal transport of a macromolecular toxin that acts at synapses in the central nervous system.

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SP - 945

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ER -

Tetanus toxin: Direct evidence for retrograde intraaxonal transport

Abstract

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