Testosterone Replacement Therapy in Men and Women

Diala El-Maouche, Adrian Dobs

Research output: Chapter in Book/Report/Conference proceedingChapter


Testosterone has received a lot of praise and also skepticism for claiming its role in "restoring youth" but a great deal is unknown about its efficacy, safety, and mechanism of action. Only recently testosterone is proving to be more than a drug for restoring sexuality; it is an important regulator of many physiologic effects. As testosterone is associated with masculinity, it has had no role in women until recently, when evidence started to show that testosterone may play a role beyond masculinity in both men and women. Androgen deficiency in women and in men is a condition that has been underdiagnosed, because little was known about the role of testosterone in both genders. In men with an established diagnosis of hypogonadism, testosterone treatment is a clear indication. For men and women with partial androgen deficiency or with unclear etiology of hypogonadism, however, the decision to initiate testosterone replacement therapy is subjective, and depends on severity and nature of symptoms. Assessment of symptoms, signs, and potential adverse events with the current data should guide the decision for a short-term trial of testosterone. As more studies are showing the potential benefits of short-term testosterone replacement, further research would have to address improved methods for diagnosing androgen deficiency, as well as the long-term safety of testosterone replacement.

Original languageEnglish (US)
Title of host publicationPrinciples of Gender-Specific Medicine
PublisherElsevier Inc.
Number of pages24
ISBN (Print)9780123742711
StatePublished - 2010

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)


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