Testosterone as a modulator of vascular behavior.

Marguerite Littleton-Kearney, Patricia D. Hurn

Research output: Contribution to journalArticle

Abstract

Male sex is an acknowledged risk factor for many forms of cardiovascular disease, and vascular disease prevalence patterns appear to be different in men versus women. The vascular properties of the principal mammalian androgen, testosterone, are complex and linked to dose, duration of exposure, presence of underlying vascular disease, and, possibly, biological sex. Data from isolated vessels and animal models suggest that pharmacological doses of testosterone, or its potent intracellular metabolite dihydrotestosterone, produce vasodilation. Testosterone's major effect on vascular beds at physiologic concentrations remains unclear, with documentation of both vasodilatory and vasoconstrictive actions. Results of various studies suggest that testosterone can alter vascular tone through both endothelium-dependent and endothelium-independent mechanisms in a variety of vascular beds and vessel types. Testosterone's endothelium-dependent effects are likely mediated at least in part through nitric oxide (NO) elaboration, whereas mechanisms of endothelium-independent effects involve 1 or more types of smooth muscle ion conductance channels. Data from clinical studies indicate that, in men, androgen replacement may provide beneficial effects when coronary artery disease is present. Conversely, in women, testosterone may augment existing hypertension, increase risk for cardiovascular events, or promote atherogenesis. However, it should be emphasized that most of these observations are anecdotal or come from small-scale clinical studies, and limited information is available in women. New research is required to understand the potential efficacy of androgen therapy, or lack thereof. This review focuses on current understanding of testosterone's physiological effects on vascular behavior and of testosterone's putative role in vascular health and disease.

Original languageEnglish (US)
Pages (from-to)276-285
Number of pages10
JournalBiological Research for Nursing
Volume5
Issue number4
StatePublished - Apr 2004

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Blood Vessels
Testosterone
Endothelium
Vascular Diseases
Androgens
Dihydrotestosterone
Ion Channels
Vasodilation
Documentation
Smooth Muscle
Coronary Artery Disease
Atherosclerosis
Nitric Oxide
Cardiovascular Diseases
Animal Models
Pharmacology
Hypertension
Health
Research

ASJC Scopus subject areas

  • Research and Theory

Cite this

Littleton-Kearney, M., & Hurn, P. D. (2004). Testosterone as a modulator of vascular behavior. Biological Research for Nursing, 5(4), 276-285.

Testosterone as a modulator of vascular behavior. / Littleton-Kearney, Marguerite; Hurn, Patricia D.

In: Biological Research for Nursing, Vol. 5, No. 4, 04.2004, p. 276-285.

Research output: Contribution to journalArticle

Littleton-Kearney, M & Hurn, PD 2004, 'Testosterone as a modulator of vascular behavior.', Biological Research for Nursing, vol. 5, no. 4, pp. 276-285.
Littleton-Kearney M, Hurn PD. Testosterone as a modulator of vascular behavior. Biological Research for Nursing. 2004 Apr;5(4):276-285.
Littleton-Kearney, Marguerite ; Hurn, Patricia D. / Testosterone as a modulator of vascular behavior. In: Biological Research for Nursing. 2004 ; Vol. 5, No. 4. pp. 276-285.
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