Testosterone and depressive symptoms among men in the Diabetes Prevention Program

on behalf of the Diabetes Prevention Program Research Group

Research output: Contribution to journalArticle


Objective We examined associations between intensive lifestyle intervention (ILS) and changes in testosterone and associations with mood among middle-aged men. Design Secondary analysis of men (n = 886) participating in the Diabetes Prevention Program which randomized glucose-intolerant, overweight men to ILS, metformin, or placebo between 1996 and 1999. Main outcome measures Changes in testosterone between baseline and 1-year follow-up asnd associations of these changes with mood measures (Beck Depression Inventory [BDI-II], Beck Anxiety Inventory [BAI]). Results Median baseline testosterone was 10.98 nmol/l and 44% (n = 385) had testosterone 

Original languageEnglish (US)
Pages (from-to)63-71
Number of pages9
StatePublished - Oct 1 2016


  • Androgens
  • Glucose-intolerance
  • Mood
  • Testosterone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems

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