Testis function in rhesus monkeys treated with a contraceptive steroid formulation

L. L. Ewing, R. C. Cochran, R. J. Adams, K. J. Darney, S. J. Berry, M. J. Bordy, C. Desjardins

Research output: Contribution to journalArticle

Abstract

Rhesus monkeys (Macaca mulatta) were treated with testosterone (100μg/kg/day) plus estradiol (0.5μg/kg/day) via subcutaneous polydimethylsiloxane (PDS;Silastic) implants for thirteen months. This steroid regimen inhibited LH but not FSH secretion by the anterior pituitary, inhibited testicular testosterone and estradiol production and drastically reduced the numbers of vigorously motile spermatozoa in the ejacula. Importantly, these effects on testis function were achieved at dosages of testosterone and estradiol which approximate the amount of these two steroids produced daily in normal rhesus males.

Original languageEnglish (US)
Pages (from-to)347-362
Number of pages16
JournalContraception
Volume27
Issue number4
DOIs
StatePublished - Apr 1983

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Ewing, L. L., Cochran, R. C., Adams, R. J., Darney, K. J., Berry, S. J., Bordy, M. J., & Desjardins, C. (1983). Testis function in rhesus monkeys treated with a contraceptive steroid formulation. Contraception, 27(4), 347-362. https://doi.org/10.1016/S0010-7824(83)80015-8