TY - JOUR
T1 - Testing homogeneity in semiparametric mixture case–control models
AU - Di, Chong Zhi
AU - Chan, Kwun Chuen Gary
AU - Zheng, Cheng
AU - Liang, Kung Yee
N1 - Publisher Copyright:
© 2017 Taylor & Francis Group, LLC.
PY - 2017/9/17
Y1 - 2017/9/17
N2 - Parametric and semiparametric mixture models have been widely used in applications from many areas, and it is often of interest to test the homogeneity in these models. However, hypothesis testing is non standard due to the fact that several regularity conditions do not hold under the null hypothesis. We consider a semiparametric mixture case–control model, in the sense that the density ratio of two distributions is assumed to be of an exponential form, while the baseline density is unspecified. This model was first considered by Qin and Liang (2011, biometrics), and they proposed a modified score statistic for testing homogeneity. In this article, we consider alternative testing procedures based on supremum statistics, which could improve power against certain types of alternatives. We demonstrate the connection and comparison among the proposed and existing approaches. In addition, we provide a unified theoretical justification of the supremum test and other existing test statistics from an empirical likelihood perspective. The finite-sample performance of the supremum test statistics was evaluated in simulation studies.
AB - Parametric and semiparametric mixture models have been widely used in applications from many areas, and it is often of interest to test the homogeneity in these models. However, hypothesis testing is non standard due to the fact that several regularity conditions do not hold under the null hypothesis. We consider a semiparametric mixture case–control model, in the sense that the density ratio of two distributions is assumed to be of an exponential form, while the baseline density is unspecified. This model was first considered by Qin and Liang (2011, biometrics), and they proposed a modified score statistic for testing homogeneity. In this article, we consider alternative testing procedures based on supremum statistics, which could improve power against certain types of alternatives. We demonstrate the connection and comparison among the proposed and existing approaches. In addition, we provide a unified theoretical justification of the supremum test and other existing test statistics from an empirical likelihood perspective. The finite-sample performance of the supremum test statistics was evaluated in simulation studies.
KW - Case-control study
KW - mixture models
KW - semiparametric models
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U2 - 10.1080/03610926.2016.1205612
DO - 10.1080/03610926.2016.1205612
M3 - Article
C2 - 29725157
AN - SCOPUS:85019714355
SN - 0361-0926
VL - 46
SP - 9092
EP - 9100
JO - Communications in Statistics - Theory and Methods
JF - Communications in Statistics - Theory and Methods
IS - 18
ER -