Testing gene by community disadvantage moderation of sexual health outcomes among urban women

Research output: Contribution to journalArticle

Abstract

We examined whether the interplay between community disadvantage and a conduct disorder polygenic risk score (CD PRS) was associated with sexual health outcomes among urban women. Participants (N = 511; 75.5% African American) were originally recruited to participate in a school-based intervention and were followed into adulthood. Community disadvantage was calculated using census data when participants were in first grade. At age 20, blood or saliva samples were collected and participants reported on their condom use, sexual partners, and sexually transmitted infections. A CD PRS was created based on a genome-wide association study conducted by Dick et al. [2010]. Higher levels of community disadvantage was associated with greater sexually transmitted infections among women with a higher CD PRS. Implications of the study findings are discussed.

Original languageEnglish (US)
Article numbere0223311
JournalPloS one
Volume14
Issue number10
DOIs
StatePublished - Jan 1 2019

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Conduct Disorder
Reproductive Health
sexually transmitted diseases
Genes
Health
Sexually Transmitted Diseases
Testing
census data
genes
Sexual Partners
Genome-Wide Association Study
testing
Condoms
Censuses
African Americans
saliva
adulthood
Saliva
Blood
blood

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Testing gene by community disadvantage moderation of sexual health outcomes among urban women. / Powell, Terrinieka W.; Rabinowitz, Jill A.; Kaufman, Michelle R.; Milam, Adam J.; Benke, Kelly; Sisto, Danielle Y.; Uhl, George; Maher, Brion S.; Ialongo, Nicholas S.

In: PloS one, Vol. 14, No. 10, e0223311, 01.01.2019.

Research output: Contribution to journalArticle

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