Testing conclusions from functional imaging of working memory with data from acute stroke

Lisa E. Philipose, Hannah Alphs, Vivek Prabhakaran, Argye E. Hillis

Research output: Contribution to journalArticlepeer-review

Abstract

Functional imaging studies indicate that the left hemisphere mediates verbal working memory, while the right hemisphere mediates both verbal and spatial working memory. We evaluated acute stroke patients with working memory tests and imaging to identify whether unilateral dysfunction causes deficits in spatial and/or verbal working memory deficits. While left cortical stroke patients had verbal working memory impairments (p<0.003), right cortical stroke patients had both verbal p<0.007) and spatial working memory (p<0.03) impairments, confirming functional imaging results. Patients with transient ischemic stroke and patients with non-cortical stroke did not have significant deficits in working memory in either modality.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalBehavioural neurology
Volume18
Issue number1
DOIs
StatePublished - 2007

Keywords

  • Acute stroke
  • Diffusion-weighted imaging
  • Magnetic resonance perfusion-weighted imaging
  • Working memory

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Clinical Neurology

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