Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT2A) receptors in older, healthy adults

Tiffany W. Chow, David C. Mamo, Hiroyuki Uchida, Ariel Graff-Guerrero, Sylvain Houle, Gwenn Smith, Bruce G. Pollock, Benoit H. Mulsant

Research output: Contribution to journalArticle


Background: Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-HT2A receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin 5HT2A receptor (5HT2AR) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65-78 years) completed two [18F]-setoperone PET scans on two separate occasions 5-16 weeks apart. Results: The average difference in the binding potential (BPND) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion: We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other 5HT2AR radiotracers in younger subject samples.

Original languageEnglish (US)
Article number12
JournalBMC Medical Imaging
Publication statusPublished - Jul 6 2009
Externally publishedYes


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this