Abstract
Introduction Previous investigations of test-retest reliability of cerebral blood flow (CBF) at rest measured with pseudo-continuous Arterial Spin Labeling (pCASL) demonstrated good reliability, but are limited by the use of similar scanner platforms. In the present study we examined test-retest reliability of CBF in regions implicated in emotion and the default mode network. Material and methods We measured absolute and relative CBF at rest in thirty-one healthy subjects in two scan sessions, one week apart, at four different sites and three different scan platforms. We derived CBF from pCASL images with an automated algorithm and calculated intra-class correlation coefficients (ICCs) across sessions for regions of interest. In addition, we investigated site effects. Results For both absolute and relative CBF measures, ICCs were good to excellent (i.e. > 0.6) in most brain regions, with highest values observed for the subgenual anterior cingulate cortex and ventral striatum. A leave-one-site-out cross validation analysis did not show a significant effect for site on whole brain CBF and there was no proportional bias across sites. However, a significant site effect was present in the repeated measures ANOVA. Conclusions The high test-retest reliability of CBF measured with pCASL in a range of brain regions implicated in emotion and salience processing, emotion regulation, and the default mode network, which have been previously linked to depression symptomatology supports its use in studies that aim to identify neuroimaging biomarkers of treatment response.
| Language | English (US) |
|---|---|
| Pages | 26-33 |
| Number of pages | 8 |
| Journal | Magnetic Resonance Imaging |
| Volume | 45 |
| DOIs | |
| State | Published - Jan 1 2018 |
| Externally published | Yes |
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Keywords
- Arterial spin labeling
- Cerebral blood flow
- fMRI
- Reliability
ASJC Scopus subject areas
- Biophysics
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging
Cite this
Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling : Findings from the EMBARC study. / Almeida, Jorge R.C.; Greenberg, Tsafrir; Lu, Hanzhang; Chase, Henry W.; Fournier, Jay; Cooper, Crystal M.; Deckersbach, Thilo; Adams, Phil; Carmody, Thomas; Fava, Mauricio; Kurian, Benji; McGrath, Patrick J.; McInnis, Melvin G.; Oquendo, Maria A.; Parsey, Ramin; Weissman, Myrna; Trivedi, Madhukar; Phillips, Mary L.
In: Magnetic Resonance Imaging, Vol. 45, 01.01.2018, p. 26-33.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Test-retest reliability of cerebral blood flow in healthy individuals using arterial spin labeling
T2 - Magnetic Resonance Imaging
AU - Almeida,Jorge R.C.
AU - Greenberg,Tsafrir
AU - Lu,Hanzhang
AU - Chase,Henry W.
AU - Fournier,Jay
AU - Cooper,Crystal M.
AU - Deckersbach,Thilo
AU - Adams,Phil
AU - Carmody,Thomas
AU - Fava,Mauricio
AU - Kurian,Benji
AU - McGrath,Patrick J.
AU - McInnis,Melvin G.
AU - Oquendo,Maria A.
AU - Parsey,Ramin
AU - Weissman,Myrna
AU - Trivedi,Madhukar
AU - Phillips,Mary L.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Introduction Previous investigations of test-retest reliability of cerebral blood flow (CBF) at rest measured with pseudo-continuous Arterial Spin Labeling (pCASL) demonstrated good reliability, but are limited by the use of similar scanner platforms. In the present study we examined test-retest reliability of CBF in regions implicated in emotion and the default mode network. Material and methods We measured absolute and relative CBF at rest in thirty-one healthy subjects in two scan sessions, one week apart, at four different sites and three different scan platforms. We derived CBF from pCASL images with an automated algorithm and calculated intra-class correlation coefficients (ICCs) across sessions for regions of interest. In addition, we investigated site effects. Results For both absolute and relative CBF measures, ICCs were good to excellent (i.e. > 0.6) in most brain regions, with highest values observed for the subgenual anterior cingulate cortex and ventral striatum. A leave-one-site-out cross validation analysis did not show a significant effect for site on whole brain CBF and there was no proportional bias across sites. However, a significant site effect was present in the repeated measures ANOVA. Conclusions The high test-retest reliability of CBF measured with pCASL in a range of brain regions implicated in emotion and salience processing, emotion regulation, and the default mode network, which have been previously linked to depression symptomatology supports its use in studies that aim to identify neuroimaging biomarkers of treatment response.
AB - Introduction Previous investigations of test-retest reliability of cerebral blood flow (CBF) at rest measured with pseudo-continuous Arterial Spin Labeling (pCASL) demonstrated good reliability, but are limited by the use of similar scanner platforms. In the present study we examined test-retest reliability of CBF in regions implicated in emotion and the default mode network. Material and methods We measured absolute and relative CBF at rest in thirty-one healthy subjects in two scan sessions, one week apart, at four different sites and three different scan platforms. We derived CBF from pCASL images with an automated algorithm and calculated intra-class correlation coefficients (ICCs) across sessions for regions of interest. In addition, we investigated site effects. Results For both absolute and relative CBF measures, ICCs were good to excellent (i.e. > 0.6) in most brain regions, with highest values observed for the subgenual anterior cingulate cortex and ventral striatum. A leave-one-site-out cross validation analysis did not show a significant effect for site on whole brain CBF and there was no proportional bias across sites. However, a significant site effect was present in the repeated measures ANOVA. Conclusions The high test-retest reliability of CBF measured with pCASL in a range of brain regions implicated in emotion and salience processing, emotion regulation, and the default mode network, which have been previously linked to depression symptomatology supports its use in studies that aim to identify neuroimaging biomarkers of treatment response.
KW - Arterial spin labeling
KW - Cerebral blood flow
KW - fMRI
KW - Reliability
UR - http://www.scopus.com/inward/record.url?scp=85029804464&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029804464&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2017.09.004
DO - 10.1016/j.mri.2017.09.004
M3 - Article
VL - 45
SP - 26
EP - 33
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
ER -