TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Patrick J. Killela, Zachary J. Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A. Diaz, Allan H. Friedman, Henry Friedman, Gary L Gallia, Beppino C. Giovanella, Arthur P. Grollman, Tong Chuan He, Yiping He, Ralph H Hruban, George Jallo, Nils Mandahl, Alan Keith Meeker, Fredrik Mertens, George J. Netto, B. Ahmed Rasheed & 17 others Gregory J Riggins, Thomas A. Rosenquist, Mark Schiffman, Ie Ming Shih, Dan Theodorescu, Michael S. Torbenson, Victor E Velculescu, Tian-Li Wang, Nicolas Wentzensen, Laura Delong Wood, Ming Zhang, Roger E. McLendon, Darell D. Bigner, Kenneth W Kinzler, Bert Vogelstein, Nickolas Papadopoulos, Hai Yan

Research output: Contribution to journalArticle

Abstract

Malignant cells, like all actively growing cells, must maintain their telomeres, but genetic mechanisms responsible for telomere maintenance in tumors have only recently been discovered. In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance mechanism not involving telomerase (alternative lengthening of telomeres), and point mutations in the promoter of the telomerase reverse transcriptase (TERT) gene increase telomerase expression and have been shown to occur in melanomas and a small number of other tumors. To further define the tumor types in which this latter mechanism plays a role, we surveyed 1,230 tumors of 60 different types. We found that tumors could be divided into types with low (

Original languageEnglish (US)
Pages (from-to)6021-6026
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number15
DOIs
StatePublished - Apr 9 2013

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Telomerase
Glioma
Telomere
Mutation
Neoplasms
Telomere-Binding Proteins
Telomere Homeostasis
Maintenance
Point Mutation
Melanoma
Genes
Proteins

ASJC Scopus subject areas

  • General

Cite this

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. / Killela, Patrick J.; Reitman, Zachary J.; Jiao, Yuchen; Bettegowda, Chetan; Agrawal, Nishant; Diaz, Luis A.; Friedman, Allan H.; Friedman, Henry; Gallia, Gary L; Giovanella, Beppino C.; Grollman, Arthur P.; He, Tong Chuan; He, Yiping; Hruban, Ralph H; Jallo, George; Mandahl, Nils; Meeker, Alan Keith; Mertens, Fredrik; Netto, George J.; Ahmed Rasheed, B.; Riggins, Gregory J; Rosenquist, Thomas A.; Schiffman, Mark; Shih, Ie Ming; Theodorescu, Dan; Torbenson, Michael S.; Velculescu, Victor E; Wang, Tian-Li; Wentzensen, Nicolas; Wood, Laura Delong; Zhang, Ming; McLendon, Roger E.; Bigner, Darell D.; Kinzler, Kenneth W; Vogelstein, Bert; Papadopoulos, Nickolas; Yan, Hai.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 15, 09.04.2013, p. 6021-6026.

Research output: Contribution to journalArticle

Killela, PJ, Reitman, ZJ, Jiao, Y, Bettegowda, C, Agrawal, N, Diaz, LA, Friedman, AH, Friedman, H, Gallia, GL, Giovanella, BC, Grollman, AP, He, TC, He, Y, Hruban, RH, Jallo, G, Mandahl, N, Meeker, AK, Mertens, F, Netto, GJ, Ahmed Rasheed, B, Riggins, GJ, Rosenquist, TA, Schiffman, M, Shih, IM, Theodorescu, D, Torbenson, MS, Velculescu, VE, Wang, T-L, Wentzensen, N, Wood, LD, Zhang, M, McLendon, RE, Bigner, DD, Kinzler, KW, Vogelstein, B, Papadopoulos, N & Yan, H 2013, 'TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 15, pp. 6021-6026. https://doi.org/10.1073/pnas.1303607110
Killela, Patrick J. ; Reitman, Zachary J. ; Jiao, Yuchen ; Bettegowda, Chetan ; Agrawal, Nishant ; Diaz, Luis A. ; Friedman, Allan H. ; Friedman, Henry ; Gallia, Gary L ; Giovanella, Beppino C. ; Grollman, Arthur P. ; He, Tong Chuan ; He, Yiping ; Hruban, Ralph H ; Jallo, George ; Mandahl, Nils ; Meeker, Alan Keith ; Mertens, Fredrik ; Netto, George J. ; Ahmed Rasheed, B. ; Riggins, Gregory J ; Rosenquist, Thomas A. ; Schiffman, Mark ; Shih, Ie Ming ; Theodorescu, Dan ; Torbenson, Michael S. ; Velculescu, Victor E ; Wang, Tian-Li ; Wentzensen, Nicolas ; Wood, Laura Delong ; Zhang, Ming ; McLendon, Roger E. ; Bigner, Darell D. ; Kinzler, Kenneth W ; Vogelstein, Bert ; Papadopoulos, Nickolas ; Yan, Hai. / TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. In: Proceedings of the National Academy of Sciences of the United States of America. 2013 ; Vol. 110, No. 15. pp. 6021-6026.
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AU - Killela, Patrick J.

AU - Reitman, Zachary J.

AU - Jiao, Yuchen

AU - Bettegowda, Chetan

AU - Agrawal, Nishant

AU - Diaz, Luis A.

AU - Friedman, Allan H.

AU - Friedman, Henry

AU - Gallia, Gary L

AU - Giovanella, Beppino C.

AU - Grollman, Arthur P.

AU - He, Tong Chuan

AU - He, Yiping

AU - Hruban, Ralph H

AU - Jallo, George

AU - Mandahl, Nils

AU - Meeker, Alan Keith

AU - Mertens, Fredrik

AU - Netto, George J.

AU - Ahmed Rasheed, B.

AU - Riggins, Gregory J

AU - Rosenquist, Thomas A.

AU - Schiffman, Mark

AU - Shih, Ie Ming

AU - Theodorescu, Dan

AU - Torbenson, Michael S.

AU - Velculescu, Victor E

AU - Wang, Tian-Li

AU - Wentzensen, Nicolas

AU - Wood, Laura Delong

AU - Zhang, Ming

AU - McLendon, Roger E.

AU - Bigner, Darell D.

AU - Kinzler, Kenneth W

AU - Vogelstein, Bert

AU - Papadopoulos, Nickolas

AU - Yan, Hai

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