Tenofovir exposure alters associations of serum bicarbonate with chronic kidney disease risk in HIV-infected Veterans

Julie Kim, Rebecca Scherzer, Michelle Estrella, Joachim Ix, Michael Shlipak

Research output: Contribution to journalArticle

Abstract

OBJECTIVE:: Among HIV-infected persons, tenofovir disoproxil fumarate (TDF) use is associated with higher risk of developing chronic kidney disease (CKD). Because lower serum bicarbonate concentrations may precede CKD onset, this study investigated the associations between TDF use and bicarbonate concentrations, and between bicarbonate with CKD risk among TDF users and non-users. METHODS:: Retrospective cohort study of 16,070 HIV-infected US veterans who initiated antiretroviral therapy between 1997–2011. The association between TDF use with longitudinal bicarbonate concentrations and associations between bicarbonate with incident CKD stratified by TDF use (never, initial, and later user) were evaluated. RESULTS:: Compared to TDF users, never users had faster declines in bicarbonate concentrations: change in bicarbonate -0.11?mmol/L/year (95% CI -0.16, -0.05), compared with -0.04?mmol/L/year (-0.06, 0.05) in initial users and -0.02?mmol/L/year (-0.05, 0.01) in later users. Low baseline bicarbonate (

Original languageEnglish (US)
JournalAIDS
DOIs
StateAccepted/In press - Jan 11 2016
Externally publishedYes

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Tenofovir
Veterans
Bicarbonates
Chronic Renal Insufficiency
HIV
Serum

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Tenofovir exposure alters associations of serum bicarbonate with chronic kidney disease risk in HIV-infected Veterans. / Kim, Julie; Scherzer, Rebecca; Estrella, Michelle; Ix, Joachim; Shlipak, Michael.

In: AIDS, 11.01.2016.

Research output: Contribution to journalArticle

Kim, Julie ; Scherzer, Rebecca ; Estrella, Michelle ; Ix, Joachim ; Shlipak, Michael. / Tenofovir exposure alters associations of serum bicarbonate with chronic kidney disease risk in HIV-infected Veterans. In: AIDS. 2016.
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abstract = "OBJECTIVE:: Among HIV-infected persons, tenofovir disoproxil fumarate (TDF) use is associated with higher risk of developing chronic kidney disease (CKD). Because lower serum bicarbonate concentrations may precede CKD onset, this study investigated the associations between TDF use and bicarbonate concentrations, and between bicarbonate with CKD risk among TDF users and non-users. METHODS:: Retrospective cohort study of 16,070 HIV-infected US veterans who initiated antiretroviral therapy between 1997–2011. The association between TDF use with longitudinal bicarbonate concentrations and associations between bicarbonate with incident CKD stratified by TDF use (never, initial, and later user) were evaluated. RESULTS:: Compared to TDF users, never users had faster declines in bicarbonate concentrations: change in bicarbonate -0.11?mmol/L/year (95{\%} CI -0.16, -0.05), compared with -0.04?mmol/L/year (-0.06, 0.05) in initial users and -0.02?mmol/L/year (-0.05, 0.01) in later users. Low baseline bicarbonate (",
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N2 - OBJECTIVE:: Among HIV-infected persons, tenofovir disoproxil fumarate (TDF) use is associated with higher risk of developing chronic kidney disease (CKD). Because lower serum bicarbonate concentrations may precede CKD onset, this study investigated the associations between TDF use and bicarbonate concentrations, and between bicarbonate with CKD risk among TDF users and non-users. METHODS:: Retrospective cohort study of 16,070 HIV-infected US veterans who initiated antiretroviral therapy between 1997–2011. The association between TDF use with longitudinal bicarbonate concentrations and associations between bicarbonate with incident CKD stratified by TDF use (never, initial, and later user) were evaluated. RESULTS:: Compared to TDF users, never users had faster declines in bicarbonate concentrations: change in bicarbonate -0.11?mmol/L/year (95% CI -0.16, -0.05), compared with -0.04?mmol/L/year (-0.06, 0.05) in initial users and -0.02?mmol/L/year (-0.05, 0.01) in later users. Low baseline bicarbonate (

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